Institut de Chimie Moléculaire et des Matériaux d'Orsay

Frederic Avenier

Bât. 670, bureau 1311 – LCBB – ICMMO - UMR 8182
Université Paris-Saclay
Bâtiment 670
17-19 Avenue des Sciences
91400 Orsay

+33 1 69 15 47 23

Education and positions

SInce 2022 : Professor at Université Paris-Saclay

2017 : Habilitation à Diriger des Recherches" from Université Paris Sud (September 03 2017)

Since 2009 : University Lecturer at Université Paris Sud

2008-2009 : ATER (Postdoc) at ENS Lyon, Bioorganic chemistry Lab (Prof. Hasserodt).

2004-2008 : Postdoc at the University of Cambridge, UK, Department of Biochemistry (Prof. Hollfelder).

2000-2003 : PhD in Molecular Chemistry at Université Joseph Fourier, Grenoble (Supervisor: Dr. Jean-Marc Latour).


Selected Publications

Selective Formation of an FeIVO or an FeIIIOOH Intermediate From FeII-H2O2: Controlled Heterolytic vsHomolytic O-O Bond Cleavage by the Second Coordination Sphere

Angew. Chem. Int. Ed. 2019, 58, 854-858

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Aerobic Baeyer-Villiger Oxidation Catalyzed by a Flavin-Containing Enzyme Mimic in Water 

Angew. Chem. Int. Ed. 2018, 57, 16412-16415

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A Growing Family of OActivating Dinuclear Iron Enzymes with Key Catalytic Diiron(III)-peroxo Intermediates: Biological Systems and Chemical Models

Coord. Chem. Rev. 2016, 322, 142-158

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Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes

Nature Communications 2015, 6, 8509

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List of publications since 2013

Interplay of chloride levels and palladium(II)-catalyzed O-deallenylation bioorthogonal uncaging reactions. G. M. Dal Forno, E. Latocheski, C. D. Navo, B. L. Albuquerque, A. L. St John, F. Avenier, G. Jiménez-Osés, J. B. Domingos, Chem. Sci., 2024, 15, 4458-4465

Unprotected Amine Transfer Performed by Non-Heme Iron(II) Complexes. A. Boullé, A. Doumbia, J.-P. Mahy, F. Avenier, Chem. Commun., 2023, 59, 79-81

Experiments and DFT Computations Combine to Decipher Fe-Catalyzed Amidine Synthesis through Nitrene Transfer and Nitrile Insertion. G. Coin, P. Dubourdeaux, F. Avenier, R. Patra, L. Castro, C. Lebrun, P.-A. Bayle, J. Pécaut, G. Blondin, P. Maldivi, J.-M. Latour, ACS Catalysis, 2021, 11, 2253-2266

Recent progress in the development of new artificial metalloenzymes as biocatalysts for selective oxidations and Diels-Alder reaction - Mini-Review. F. Avenier, W. Ghattas, R. Ricoux, J.-P. Mahy, Vietnam J. Chem., 2020, 58, 423-433

Bioinspired Symmetrical and Unsymmetrical Diiron Complexes for Selective Oxidation Catalysis with Hydrogen Peroxide. A. Trehoux, R. Guillot, M. Clémancey, G. Blondin, J.-M. Latour, J.-P. Mahy, F. Avenier, Dalton Trans., 2020, 49, 16657-16661

Characterization in Aqueous Medium of an FMN Semiquinone Radical Stabilized by the Enzyme-Like Microenvironment of a Modified Polyethyleneimine. Y. Chevalier, Y. L. T. Ki, C. Herrero, D. L. Nouen, J.-P. Mahy, J.-P. Goddard, F. Avenier, Org. Biomol. Chem., 2020, 18, 4386-4389

Aerobic Oxidation Catalyzed by Polyoxometalates Associated to an Artificial Reductase at Room Temperature and in Water. A. Naim, Y. Chevalier, Y. Bouzidi, P. Gairola, P. Mialane, A. Dolbecq, F. Avenier, J.-P. Mahy, Inorg. Chem. Frontiers, 2020, 7, 2362-2369

Artificial iron hydrogenase made by covalent grafting of Knölker's complex into xylanase: Application in asymmetric hydrogenation of an aryl ketone in water. K. Kariyawasam, W. Ghattas, Y. L. D. L. Santos, N. Doucet, S. Gaillard, J.-L. Renaud, F. Avenier, J.-P. Mahy, R. Ricoux, Biotechnol. Appl. Biochem., 2020, 67, 563-573

Selective Formation of an FeIVO or an FeIIIOOH Intermediate From Iron(II) and H2O2 : Controlled Heterolytic versus Homolytic Oxygen-Oxygen Bond Cleavage by the Second Coordination Sphere. K. Cheaib, M. Q. E. Mubarak, K. Sénéchal-David, C. Herrero, R. Guillot, M. Clémancey, J.-M. Latour, S. D. Visser, J.-P. Mahy, F. Banse, F. Avenier, Angew. Chem. Int. Ed., 2019, 58, 854-858

Aerobic Baeyer-Villiger Oxidation Catalyzed by a Flavin-Containing Enzyme Mimic in Water. Y. Chevalier, Y. L. T. Ki, D. L. Nouen, J.-P. Mahy, J.-P. Goddard, F. Avenier, Angew. Chem. Int. Ed., 2018, 57, 16412-16415

Imidazolidine Ring Cleavage upon Complexation with First Row Transition Metals. K. Cheaib, C. Herrero, R. Guillot, F. Banse, J.-P. Mahy, F. Avenier, Eur. J. Inorg. Chem., 2017, 3884-3891

Redox Self-Adaptation of a Nitrene Transfer Catalyst to the Substrate Needs. E. Gouré, D. Senthilnathan, G. Coin, F. Albrieux, F. Avenier, P. Dubourdeaux, C. Lebrun, P. Maldivi, J.-M. Latour, Angew. Chem. Intern. Ed., 2017, 56, 4305-4309

Elucidating the light-induced charge accumulation in an artificial analogue of methane monooxygenase enzymes using time-resolved x-ray absorption spectroscopy. D. Moonshiram, A. Picon, Á. Vázquez-Mayagoitia, X. Zhang, M.-F. Tu, P. Garrido-Barros, J.-P. Mahy, F. Avenier, A. Aukauloo, Chem. Commun., 2017, 53, 2725-2728

Reduction of a Tris(picolyl)amine Copper(II) Complex by an Polymeric Flavo-Reductase model in Water. K. Cheaib, Y. Roux, C. Herrero, A. Trehoux, F. Avenier, J.-P. Mahy, Dalton Trans., 2016, 45, 18098-18101

A growing family of o2 activating dinuclear iron enzymes with key catalytic diiron(III)-peroxo intermediates: biological systems and chemical models. A. Trehoux, J.-P. Mahy, F. Avenier, Coord. Chem. Rev., 2016, 322, 142-158

Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes. Y. Roux, R. Ricoux, F. Avenier, J.-P. Mahy, Nature Communications, 2015, 6, 8509

Synthesis and characterization of [Fe(BPMEN)ACC]SbF₆: a structural and functional mimic of ACC-oxidase. Y. Roux, W. Ghattas, F. Avenier, R. Guillot, A. J. Simaan, J.-P. Mahy, Dalton Trans., 2015, 44, 5966-5968

Catalytic oxidation of dibenzothiophene and thioanisole by a diiron(III) complex and hydrogen peroxide. A. Trehoux, Y. Roux, R. Guillot, J.-P. Mahy, F. Avenier, Journal of Molecular Catalysis A: Chemical, 2015, 396, 40-46

Neocarzinostatin-based hybrid biocatalysts with a RNase like activity. A. Urvoas, W. Ghattas, J.-D. Maréchal, F. Avenier, F. Bellande, W. Mao, R. Ricoux, J.-P. Mahy, Bioorg. Med. Chem., 2014, 22, 5678-5686

Photoassisted Generation of a Dinuclear Iron(III) Peroxo Species and Oxygen-Atom Transfer. F. Avenier, C. Herrero, W. Leibl, A. Desbois, R. Guillot, J.-P. Mahy, A. Aukauloo, Angew. Chem. Intern. Ed., 2013, 52, 3634-3637