Institut de Chimie Moléculaire et des Matériaux d'Orsay

David Leboeuf

                David Leboeuf
Chargé de Recherche
Bât. 420LCM – ICMMO
Université Paris-Sud
15, rue Georges Clémenceau
91405 Orsay Cedex

+33 1 69 15 47 38


Current Position

Since 10/2013: 

  • CNRS Associate Professor, Equipe de Catalyse Moléculaire, Université Paris-Sud, Université Paris-Saclay, Institut de Chimie Moléculaire et des Matériaux d’Orsay (ICMMO, UMR 8182), Orsay, France.


Previous Positions


  • Beatriu de Pinós Postdoctoral Fellow, Institute of Chemical Research of Catalonia (ICIQ), Tarragona, Spain. Advisor: Prof. Antonio M. Echavarren.


  • National Science Foundation Postdoctoral Fellow, University of Rochester, Rochester, NY, USA. Advisor: Prof. Alison J. Frontier


  • Servier Ph.D. Fellow, Université Pierre et Marie Curie (UPMC), Paris, France. Advisor: Prof. Max Malacria




  • Ph.D., Organic Chemistry, Université Pierre et Marie Curie (UPMC), Paris, France.


  • Master Degree, Organic and Bioorganic Chemistry, Université Pierre et Marie Curie (UPMC), Paris, France.


  • Engineering degree in Physics and Chemistry, specialty Chemistry, Ecole Supérieure de Physique et de Chimie Industrielle de la Ville de Paris (ESPCI), Paris, France

Scientific production


(33) Calcium(II)-Catalyzed Intermolecular Hydroarylation of Deactivated Styrenes in Hexafluoroisopropanol, Qi, C.; Gandon, V.; Lebœuf, D. Angew. Chem. Int. Ed. 2018, 43, 14245-14249

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(32) Boron Trifluoride-Mediated Trifluoromethylthiolation of N-Acyliminiums, Maury, J.; Force, G.; Darses, B.; Lebœuf, D. Adv. Synth. Catal. 2018, 362, 2752-2756.


(31) Calcium(II)-Catalyzed Intra- and Intermolecular Hydroamidation of Unactivated Alkenes in Hexafluoroisopropanol, Qi, C.; Hasenmaile, F.; Gandon, V.; Lebœuf, D. ACS Catal. 2018, 8, 1734-1739.


(30) Approach to Pactamycin Analogues Using Rhodium(II)-Catalyzed Alkene Aziridination and C(sp3)-H Amination Reactions, Rodrigues, R.; Lazib, Y.; Maury, J.; Neuville, L.; Lebœuf, D.; Dauban, P.; Darses, B. Org. Chem. Front. 2018, 5, 948-953.


(29) A Diversity-Oriented Synthesis of Cyclopenta[b]pyrroles and Related Compounds through a Calcium(II)/Copper(II) Catalytic Sequence, Marin, L.; Guillot, R.; Gandon, V.; Schulz, E.; Lebœuf, D. Org. Chem. Front. 2018, 5, 640-647.


(28) Enantioselective Gold(I)-Catalyzed Rearrangement of Cyclopropyl-Substituted 1,6-Enynes into 2-Oxocyclobutylcyclopentanes, Wu, Z.; Lebœuf, D.; Retailleau, P.; Gandon, V.; Marinetti, A.; Voituriez, A. Chem. Commun. 2017, 53, 7026-7029.


(27) Ca(II)-Catalyzed Alkenylation of N-Acyliminiums and Related Ions with Vinylboronic Acids, Qi, C.; Gandon, V.; Lebœuf, D. Adv. Synth. Catal. 2017, 359, 2671-2675.


(26) Carbon-Carbon and Carbon-Heteroatom Bond-Forming Transformations Catalyzed by Calcium(II) Triflimide, Lebœuf, D.; Gandon, V. Synthesis 2017, 49, 1500-1508.


(25) Catalytic Activity of Au(I) Complexes with Hemilabile P,N-Ligands, Michelet, B., Lebœuf, D.; Bour, C.; Škoch, K.; Horký, F.; Štěpnička, P.; Gandon, V. ChemPlusChem 2017, 82, 442-448.


(24) One-Pot Assembly of Highly Functionalized Cyclopenta[b]pyrroles via a Calcium(II)- and Copper(II)-Catalyzed Reaction Sequence, Marin, L.; Gandon, V.; Schulz, E.; Lebœuf, D. Adv. Synth. Catal. 2017, 359, 1157-1163.


(23) Calcium-Catalyzed Synthesis of Polysubstituted 2-Alkenylfurans From β-Keto Esters Tethered to Propargyl Alcohols, Morcillo, S. P.; Lebœuf, D.; Bour, C.; Gandon, V. Chem. Eur. J. 2016, 22, 16974-16978.


(22) Harnessing the Lewis Acidity of HFIP Through its Cooperation with a Calcium(II) Salt: Application to the aza-Piancatelli Reaction, Lebœuf, D.; Marin, L.; Michelet, B.; Perez-Luna, A.; Guillot, R.; Schulz, E.; Gandon, V. Chem. Eur. J. 2016, 22, 16165-16171.


(21) Calcium(II)-Catalyzed Alkenylation of Alcohols with Vinylboronic Acids, Lebœuf, D.; Presset, M.; Michelet, B.; Bour, C.; Bezzenine-Lafollée, S.; Gandon, V. Chem. Eur. J. 2015, 21, 11001-11005.

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(20) Calcium(II)-Catalyzed Aza-Piancatelli Reaction, Lebœuf, D.; Schulz, E.; Gandon, V. Org. Lett. 2014, 16, 6464-6468.


(19) Intermolecular Reactions of Gold(I)-Carbenes with Furans by Related Mechanisms, Lebœuf, D.; Gaydou, M.; Wang, Y., Echavarren, A. M. Org. Chem. Front. 2014, 1, 759-764.


(18) Gold(I)-Catalyzed Iodination of Arenes, Lebœuf, D.; Ciesielski, J.; Frontier, A. J. Synlett 2014, 25, 399-402.


(17) Dissecting Anion Effects in Gold(I)-Catalyzed Intermolecular Cycloadditions, Homs, A.; Obradors, C.; Lebœuf, D.; Echavarren, A. M. Adv. Synth. Catal. 2014, 356, 221-228.

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(16) Access to the Protoilludane Core by Gold-Catalyzed Allene-Vinylcyclopropane Cycloisomerization, Pitaval, A.; Lebœuf, D.; Ceccon, J.; Echavarren, A. M. Org. Lett. 2013, 15, 4580-4583.


(15) Gold(III) Chloride-Catalyzed 6-endo-trig Oxa-Michael Addition Reactions for Diastereoselective Synthesis of Fused Tetrahydropyranones, Ciesielski, J.; Lebœuf, D.; Stern, H. A.; Frontier, A. J. Adv. Synth. Catal. 2013, 355, 2077-2082.

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(14) Intermolecular Gold(I)-Catalyzed Cyclization of Furans with Alkynes: Formation of Phenols and Indenes, Huguet, N.; Lebœuf, D.; Echavarren, A. M. Chem. Eur. J. 2013, 19, 6581-6585.

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(13) Gold(I)-Catalyzed Macrocyclization of 1,n-Enynes, Obradors, C.; Lebœuf, D.; Aydin, J.; Echavarren, A. M. Org. Lett. 2013, 15, 1576-1579.


(12) Highly Enantioselective Rhodium-Catalyzed [2+2+2]-Cycloaddition of Diynes to Sulfonimines, Amatore, M.; Lebœuf, D.; Malacria, M.; Gandon, V.; Aubert, C. J. Am. Chem. Soc. 2013, 135, 4576-4579. Highlighted in Synfacts.


(11) Efficient Nazarov Cyclization/Wagner-Meerwein Rearrangement Terminated by a Cu(II)-Promoted Oxidation: Synthesis of 4-Alkylidene Cyclopentenones, Lebœuf, D.; Theiste, E.; Gandon, V.; Daifuku, S. L.; Neidig, M. L.; Frontier, A. J. Chem. Eur. J. 2013, 19, 4842-4848.

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(10) Reagent Control of [1,2]-Wagner-Meerwein Shift Chemoselectivity following Nazarov Cyclization: Application to the Total Synthesis of Enokipodin B, Lebœuf, D.; Wright, C. M.; Frontier, A. J. Chem. Eur. J. 2013, 19, 4835-4841.

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(9) Experimental and Theoretical Studies on the Nazarov Cyclization/Wagner-Meerwein Rearrangement Sequence, Lebœuf, D.; Gandon, V.; Ciesielski, J.; Frontier, A. J. J. Am. Chem. Soc. 2012, 134, 6296-6308. Highlighted in Synfacts.


(8) Using Nazarov Electrocyclization to Stage Chemoselective [1,2]-Migrations: Stereoselective Synthesis of Functionalized Cyclopentenones, Lebœuf, D.; Huang, J.; Gandon, V.; Frontier, A. J. Angew. Chem. Int. Ed. 2011, 50, 10981-10985. Highlighted in Synfacts.

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(7) Au-Catalyzed 1,3-Acyloxy Migration/5-exo-dig Cyclization/1,5-Acyl Migration of Diynyl Esters, Lebœuf, D.; Simonneau, A.; Aubert, C.; Malacria, M.; Gandon, V.; Fensterbank, L. Angew. Chem. Int. Ed. 2011, 50, 6868-6871.

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(6) Understanding the Fate of the Oxyallyl Cation Following Nazarov Electrocyclization: Sequential Wagner-Meerwein Migrations and the Synthesis of Spirocyclic Cyclopentenones, Huang, J.; Lebœuf, D.; Frontier, A. J. J. Am. Chem. Soc. 2011, 133, 6307-6317.


(5) Cobalt-Mediated Liner 2:1 Co-oligomerization of Alkynes with Enol Ethers to Give 1-Alkoxy-1,3,5-Trienes: A Missing Mode of Reactivity, Lebœuf, D.; Iannazzo, L.; Geny, A.; Malacria, M.; Vollhardt, K. P. C.; Aubert, C.; Gandon, V. Chem. Eur. J. 2010, 16, 8904-8913.

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(4) Synthesis of Tricyclic Fused 3-Aminopyridines via Intramolecular Co(I)-Catalyzed [2+2+2] Cycloaddition between Ynamides, Nitriles, and Alkynes, Garcia, P.; Moulin, S.; Miclo, Y.; Lebœuf, D.; Gandon, V.; Aubert, C.; Malacria, M. Chem. Eur. J. 2009, 15, 2129-2139.

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(3) Cobalt(I)-Mediated Preparation of Polyborylated Cyclohexadienes: Scope, Limitations, and Mechanistic Insight, Geny, A.; Lebœuf, D.; Rouquié, G.; Vollhardt, K. P. C.; Malacria, M.; Gandon, V.; Aubert, C. Chem. Eur. J. 2007, 13, 5408-5425.

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(2) Molecular Bond Formation between Surfaces: Anchoring and Shearing Effects, Lebœuf, D.; Henry, N. Langmuir 2006, 22, 127-133.


(1) Chemo-, Regio-, and Stereoselective Cobalt-Mediated [2+2+2] Cycloaddition of Alkynyl Boronates to Alkenes: 1,3- and 1,4-Diboryl-1,3-Cyclohexadienes, Gandon, V.; Lebœuf, D.; Amslinger, S.; Vollhardt, K. P. C.; Malacria, M.; Aubert, C. Angew. Chem. Int. Ed. 2005, 44, 7114-7118.