2.10. Métalloenzymes artificielles pour la théranostique
Agents targeting diseased tissue and combining diagnostic tools with therapeutics to combat different aspects of a disease are of major societal interest. We aim at the development and the assessment of hybrid molecules comprising a drug ligand of a membrane receptor bound to a metal-based catalyst.
These hybrid molecules will be designed to target drug 1 receptor in the affected tissue, wherein they will form artificial metalloenzymes that would be able to convert either a pro-drug 2 into an active drug or an imaging probe from the “off” state to the “on” state,respectively, at their target.