Institut de Chimie Moléculaire et des Matériaux d'Orsay

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Chimie Bioorganique et Bioinorganique

Publications de l'équipe


Arylboronate prodrugs of doxorubicin as promising chemotherapy for pancreatic cancer. C. Skarbek, S. Serra, H. Maslah, E. Rascol, R. Labruère, Bioorg. Chem., 2019, 91, 103158

Spermine-NBD as fluorescent probe for studies of the polyamine transport system in Leishmania donovani. E. Jagu, S. Pomel, S. Pethe, J.-C. Cintrat, P. M. Loiseau, R. Labruère, Bioorg. Med. Chem. Lett., 2019, 29, 1710-1713

Functionalized Artificial Bidomain Proteins Based on an α-Solenoid Protein Repeat Scaffold: A New Class of Artificial Diels–Alderases. T. Di Meo, K. Kariyawasam, W. Ghattas, M. Valerio-Lepiniec, G. Sciortino, J.-D. Maréchal, P. Minard, J.-P. Mahy, A. Urvoas, R. Ricoux, ACS Omega, 2019, 4, 4437-4447

Impedimetric array in polymer microfluidic cartridge for low cost point-of-care diagnostics. A. Lakey, Z. Ali, S. M. Scott, S. Chebil, H. K. Youssoufi, S. Hunor, A. Ohlander, M. Kuphal, J. S. Marti, Biosens. Bioelectron., 2019, 129, 147-154

E-DNA detection of rpoB gene resistance in Mycobacterium tuberculosis in real samples using Fe3O4/polypyrrole nanocomposite. M. Haddaoui, C. Sola, N. Raouafi, H. Korri-Youssoufi, Biosens. Bioelectron., 2019, 128, 76-82

Selective Formation of an FeIVO or an FeIIIOOH Intermediate From FeII-H2O2 : Controlled Heterolytic vs Homolytic O-O Bond Cleavage by the Second Coordination Sphere. K. Cheaib, M. Q. E. Mubarak, K. Sénéchal-David, C. Herrero, R. Guillot, M. Clémancey, J.-M. Latour, S. D. Visser, J.-P. Mahy, F. Banse, F. Avenier, Angew. Chem. Int. Ed., 2019, 58, 854-858


Bisphosphonate inhibitors of mammalian glycolytic aldolase. P. Heron, M. Abellán-Flos, L. Salmon, J. Sygusch, J. Med. Chem., 2018, 61, 10558-10572

Incorporation of a minimal nucleotide into DNA. P. Röthlisberger, F. Levi-Acobas, I. Sarac, R. Ricoux, J.-P. Mahy, P. Herdewijn, P. Marlière, M. Hollenstein, Tetrahedron Lett., 2018, 59, 4241-4244

Aerobic Baeyer-Villiger Oxidation Catalyzed by a Flavin-Containing Enzyme Mimic in Water. Y. Chevalier, Y. L. T. Ki, D. L. Nouen, J.-P. Mahy, J.-P. Goddard, F. Avenier, Angew. Chem. Intern. Ed., 2018, 57, 16412-16415

Enzyme encapsulation in mesoporous Metal-Organic Frameworks for selective biodegradation of harmful dye molecules. E. Gkaniatsou, C. Sicard, R. Ricoux, L. Benahmed, F. Bourdreux, Q. Zhang, C. Serre, J.-P. Mahy, N. Steunou, Angew. Chem. Intern. Ed., 2018, 57, 16141-16146

Receptor-based artificial metalloenzymes on living human cells. W. Ghattas, V. Dubosclard, A. Wick, A. Bendelac, R. Guillot, R. Ricoux, J.-P. Mahy, J. Am. Chem. Soc., 2018, 140, 8756-8762

A chemically-encoded timer for dual molecular delivery at tailored ranges and concentrations. S. Serra, A. Alouane, T. Le Saux, S. Huvelle, A. Alouane, R. Plasson, F. Schmidt, R. Labruère, Chem. Commun., 2018, 54, 6396-6399

Crystal Structure of Phosphomannose Isomerase from Candida albicans Complexed with 5‐Phospho‐D‐Arabinonhydrazide. L. Ahmad, S. Plancqueel, V. Dubosclard, N. Lazar, W. Ghattas, I. Li De La Sierra‐gallay, H. Van Tilbeurgh, L. Salmon, FEBS Lett., 2018, 592, 1667-1680

Direct E-DNA sensor of Mycobacterium tuberculosis mutant strain based on new nanocomposite transducer (Fc-ac-OMPA/MWCNTs). S. Bizid, S. Blili, R. Mlika, A. Haj Said, H. Korri-Youssoufi, Talanta, 2018, 184, 475-483

Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives. E. Jagu, S. Pomel, A. Diez-Martinez, E. Rascol, S. Pethe, P. M. Loiseau, R. Labruère, Eur. J. Med. Chem., 2018, 150, 655-666


Direct Electrochemical DNA Sensor based on a new redox oligomer modified with ferrocene and carboxylic acid: Application to the detection of Mycobacterium tuberculosis mutant strain. S. Bizid, S. Blili, R. Mlika, A. Haj Said, H. Korri-Youssoufi, Anal. Chim. Acta, 2017, 994, 10-18

Polyamine-based analogs and conjugates as antikinetoplastid agents. E. Jagu, S. Pomel, S. Pethe, P. M. Loiseau, R. Labruère, Eur. J. Med. Chem., 2017, 139, 982-1015

Imidazolidine Ring Cleavage upon Complexation with First Row Transition Metals. K. Cheaib, C. Herrero, R. Guillot, F. Banse, J.-P. Mahy, F. Avenier, Eur. J. Inorg. Chem., 2017, 3884-3891

Reactions of persulfides with the heme cofactor of oxidized myoglobin and microperoxidase 11: reduction or coordination. E. Galardon, F. Huguet, C. Herrero, R. Ricoux, I. Artaud, D. Padovani, Dalton Trans., 2017, 46, 7939-7946

αRep A3: A versatile artificial scaffold for metalloenzyme design. T. Di Meo, W. Ghattas, C. Herrero, C. Velours, P. Minard, J.-P. Mahy, R. Ricoux, A. Urvoas, Chem. Eur. J., 2017, 23, 10156-10166

Direct electrochemical DNA biosensor based on reduced graphene oxide and metalloporphyrin nanocomposite. Y. Wang, H. Sauriat-Dorizon, H. Korri-Youssoufi, Sens. Actuators B: Chem., 2017, 251, 40-48

Carbohydrate-based electrochemical biosensor for detection of a cancer biomarker in human plasma. M. Devillers, L. Ahmad, H. Korri-Youssoufi, L. Salmon, Biosens. Bioelectron., 2017, 96, 178-185

Redox Self-Adaptation of a Nitrene Transfer Catalyst to the Substrate Needs. E. Gouré, D. Senthilnathan, G. Coin, F. Albrieux, F. Avenier, P. Dubourdeaux, C. Lebrun, P. Maldivi, J.-M. Latour, Angew. Chem. Intern. Ed., 2017, 56, 4305-4309

Elucidating the light-induced charge accumulation in an artificial analogue of methane monooxygenase enzymes using time-resolved x-ray absorption spectroscopy. D. Moonshiram, A. Picon, Á. Vázquez-Mayagoitia, X. Zhang, M.-F. Tu, P. Garrido-Barros, J.-P. Mahy, F. Avenier, A. Aukauloo, Chem. Commun., 2017, 53, 2725-2728

Metal–organic frameworks: a novel host platform for enzymatic catalysis and detection. E. Gkaniatsou, C. Sicard, R. Ricoux, J.-P. Mahy, N. Steunou, C. Serre, Mater. Horiz., 2017, 4, 55-63

Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates. E. Jagu, S. Pomel, A. Diez-Martinez, F. Ramiandrasoa, R. Luise Krauth-Siegel, S. Pethe, C. Blonski, R. Labruère, P. M. Loiseau, Bioorg. Med. Chem., 2017, 25, 84-90


Photoassisted Oxidation of Sulfides Catalyzed by Artificial Metalloenzymes Using Water as an Oxygen Source. C. Herrero, N. Nguyen-Thi, F. Hammerer, F. Banse, D. Gagné, N. Doucet, J.-P. Mahy, R. Ricoux, Catalysts, 2016, 6, 202

Reduction of a Tris(picolyl)amine Copper(II) Complex by an Polymeric Flavo-Reductase model in Water. K. Cheaib, Y. Roux, C. Herrero, A. Trehoux, F. Avenier, J.-P. Mahy, Dalton Trans., 2016, 45, 18098-18101

Functionalization of MWCNTs with Ferrocene-poly(p-phenylene) and Effect on Electrochemical Properties: Application as a Sensing Platform. S. Bizid, R. Mlika, A. Haj Said, M. Chemli, H. Korri-Youssoufi, Electroanalysis, 2016, 28, 2533-2542

Complexes of a Zn-metalloenzyme binding site with hydroxamate-containing ligands. A case for detailed benchmarkings of polarizable molecular mechanics/dynamics potentials when the experimental binding structure is unknown. N. Gresh, D. Perahia, B. De Courcy, J. Foret, C. Roux, L. El-Khoury, J.-P. Piquemal, L. Salmon, J. Comput. Chem., 2016, 37, 2770-2782

Large area graphene nanomesh: an artificial platform for edge-electrochemical biosensing at the sub-attomolar level. B. Zribi, J.-M. Castro-Arias, D. Decanini, N. Gogneau, D. Dragoe, A. Cattoni, A. Ouerghi, H. Korri-Youssoufi, A.-M. Haghiri-Gosnet, Nanoscale, 2016, 8, 15479-15485

A growing family of o2 activating dinuclear iron enzymes with key catalytic diiron(III)-peroxo intermediates: biological systems and chemical models. A. Trehoux, J.-P. Mahy, F. Avenier, Coord. Chem. Rev., 2016, 322, 142-158

Streptavidin-polypyrrole Film as Platform for Biotinylated Redox Probe Immobilization for Electrochemical Immunosensor Application. A. Miodek, H. Q. A. Lê, H. Sauriat-Dorizon, H. Korri-Youssoufi, Electroanalysis, 2016, 28, 1824-1832

Direct detection of OTA by impedimetric aptasensor based on modified polypyrrole-dendrimers. N. Mejri-Omrani, A. Miodek, B. Zribi, M. Marrakchi, M. Hamdi, J.-L. Marty, H. Korri-Youssoufi, Anal. Chim. Acta, 2016, 920, 37-46

Electrochemical functionalization of polypyrrole through amine oxidation of poly(amidoamine) dendrimers: Application to DNA biosensor. A. Miodek, N. Mejri-Omrani, R. Khoder, H. Korri-Youssoufi, Talanta, 2016, 154, 446-454

Investigations of poly(p-phenylene) modified with ferrocene and their application in electrochemical DNA sensing. S. Bizid, R. Mlika, A. Haj Said, M. Chemli, H. Korri-Youssoufi, Sens. Actuators B: Chem., 2016, 226, 370-380

A microfluidic electrochemical biosensor based on multiwall carbon nanotube/ferrocene for genomic DNA detection of Mycobacterium tuberculosis in clinical isolates. B. Zribi, E. Roy, A. Pallandre, S. Chebil, M. Koubaa, N. Omrani Mejri, H. M. Gomez, C. Sola, H. Korri-Youssoufi, A.-M. Haghiri-Gosnet, Biomicrofluidics, 2016, 10, 014115

Artificial Metalloenzymes with the Neocarzinostatin Scaffold: Toward a Biocatalyst for the Diels–Alder Reaction. W. Ghattas, L. Cotchico-Alonso, J.-D. Maréchal, A. Urvoas, M. Rousseau, J.-P. Mahy, R. Ricoux, ChemBioChem, 2016, 17, 433-440

Oxidation catalysis via visible-light water activation of a [Ru(bpy)3]2+ chromophore BSA-metallocorrole couple. C. Herrero, A. Quaranta, R. Ricoux, A. Trehoux, A. Mahammed, Z. Gross, F. Banse, J.-P. Mahy, Dalton Trans., 2016, 45, 706-710


Gadolinium Meso-Tetrakis(4-Pyridyl)Porphyrin as a MRI Contrast Agent: Comparison with Anionic and Cationic Metallo-Porphyrins. T. Jahanbin, H. Sauriat-Dorizon, S. Benderbous, H. Korri-Youssoufi, Journal of Colloid Science and Biotechnology, 2015, 4, 57-63

Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes. Y. Roux, R. Ricoux, F. Avenier, J.-P. Mahy, Nature Communications, 2015, 6, 8509

E-DNA Sensor of Mycobacterium tuberculosis Based on Electrochemical Assembly of Nanomaterials (MWCNTs/PPy/PAMAM). A. Miodek, N. Omrani Mejri, M. Gomgnimbou, C. Sola, H. Korri-Youssoufi, Anal. Chem., 2015, 87, 9257-9264

Development of Gd(III) porphyrin-conjugated chitosan nanoparticles as contrast agents for magnetic resonance imaging. T. Jahanbin, H. Sauriat-Dorizon, P. Spearman, S. Benderbous, H. Korri-Youssoufi, Mater. Sci. Eng. C, 2015, 52, 325-332

An Artificial Enzyme Made by Covalent Grafting of an FeII Complex into β-Lactoglobulin: Molecular Chemistry, Oxidation Catalysis, and Reaction-Intermediate Monitoring in a Protein. C. Buron, K. Sénéchal-David, R. Ricoux, J.-P. Le Caër, V. Guérineau, P. Méjanelle, R. Guillot, C. Herrero, J.-P. Mahy, F. Banse, Chem. Eur. J., 2015, 21, 12188-12193

Self-Immolative Spacers: Kinetic Aspects, Structure–Property Relationships, and Applications. A. Alouane, R. Labruère, T. Le Saux, F. Schmidt, L. Jullien, Angew. Chem. Intern. Ed., 2015, 54, 7492-7509

Entasis Through Hook-and-Loop Fastening in a Glycoligand with Cumulative Weak Forces Stabilizing CuI. L. Garcia, F. Cisnetti, N. Gillet, R. Guillot, M. Aumont-Nicaise, J.-P. Piquemal, M. Desmadril, F. Lambert, C. Policar, J. Am. Chem. Soc., 2015, 137 (3), 1141–1146

Structural Basis for Competitive Inhibition of 3,4-Dihydroxy-2-Butanone-4-Phosphate Synthase from Vibrio cholerae. Z. Islam, A. Kumar, S. Singh, L. Salmon, S. Karthikeyan, J. Biol. Chem., 2015, 290, 11293-11308

Synthesis and characterization of [Fe(BPMEN)ACC]SbF₆: a structural and functional mimic of ACC-oxidase. Y. Roux, W. Ghattas, F. Avenier, R. Guillot, A. J. Simaan, J.-P. Mahy, Dalton Trans., 2015, 44, 5966-5968

Design, synthesis and in vitro antikinetoplastid evaluation of N-acylated putrescine, spermidine and spermine derivatives. E. Jagu, R. Djilali, S. Pomel, F. Ramiandrasoa, S. Pethe, R. Labruère, P. M. Loiseau, C. Blonski, Bioorg. Med. Chem. Lett., 2015, 25, 207-209

From "hemoabzymes" to "hemozymes": towards new biocatalysts for selective oxidations. J.-P. Mahy, J.-D. Maréchal, R. Ricoux, Chemical Communications, 2015, 51, 2476-2494

Catalytic oxidation of dibenzothiophene and thioanisole by a diiron(III) complex and hydrogen peroxide. A. Trehoux, Y. Roux, R. Guillot, J.-P. Mahy, F. Avenier, Journal of Molecular Catalysis A: Chemical, 2015, 396, 40-46


Various strategies for obtaining oxidative artificial hemoproteins with a catalytic oxidative activity: from "Hemoabzymes" to "Hemozymes"? J.-P. Mahy, J.-D. Maréchal, R. Ricoux, J. Porphyrins Phthalocyanines, 2014, 18, 1063-1092

Comparative Analysis of Cellular Prion Detection by Mass-Sensitive Immunosensors. A. Poturnayova, M. Snejdarkova, L. Babelova, H. Korri-Youssoufi, T. Hianik, Electroanalysis, 2014, 26, 1312-1319

Neocarzinostatin-based hybrid biocatalysts with a RNase like activity. A. Urvoas, W. Ghattas, J.-D. Maréchal, F. Avenier, F. Bellande, W. Mao, R. Ricoux, J.-P. Mahy, Bioorg. Med. Chem., 2014, 22, 5678-5686

Catalytic C-H Amination: A Reaction Now Accessible to Engineered Natural Enzymes. J.-P. Mahy, J. Ciesielski, P. Dauban, Angew. Chem. Intern. Ed., 2014, 53, 6862-6864

Neocarzinostatin-based hybrid biocatalysts for oxidation reactions. E. Sansiaume-Dagousset, A. Urvoas, K. Chelly, W. Ghattas, J.-D. Maréchal, J.-P. Mahy, R. Ricoux, Dalton Trans., 2014, 43, 8344-8354

Direct electrochemical detection of PB1-F2 protein of influenza A virus in infected cells. A. Miodek, H. Sauriat-Dorizon, C. Chevalier, B. Delmas, J. Vidic, H. Korri-Youssoufi, Biosens. Bioelectron., 2014, 59, 6-13

Electrochemical aptasensor of cellular prion protein based on modified polypyrrole with redox dendrimers. A. Miodek, G. Castillo, T. Hianik, H. Korri-Youssoufi, Biosens. Bioelectron., 2014, 56, 104-111

Characterization of yellow bacterial laccase SmLac/role of redox mediators in azo dye decolorization. S. Galai, H. Korri-Youssoufi, M. N. Marzouki, J. Chem. Technol. Biotechnol., 2014, 89, 1741-1750

A unique 1-amino-1-cyclopropane carboxylate cupric-cryptate hosting sodium. W. Ghattas, R. Ricoux, H. Korri-Youssoufi, R. Guillot, E. Riviere, J.-P. Mahy, Dalton Trans., 2014, 43, 7708-7711

Electrochemical detection of the oligomerization of PB1-F3 influenza A virus protein in infected cells. H. Korri-Youssoufi, A. Miodek, J. Vidic, C.-A. Richard, R. Le Goffic, H. Sauriat-Dorizon, Anal. Chem., 2014, 86, 9098-9105


Electrochemical Aptasensor of Human Cellular Prion Based on Multiwalled Carbon Nanotubes Modified with Dendrimers: A Platform for Connecting Redox Markers and Aptamers. A. Miodek, G. Castillo, T. Hianik, H. Korri-Youssoufi, Anal. Chem., 2013, 85, 7704-7712

Polypyrrole functionalized with new copper complex as platform for His-tag antibody immobilization and direct antigen detection. S. Chebil, A. Miodek, V. Ambike, H. Sauriat-Dorizon, C. Policar, H. Korri-Youssoufi, Sens. Actuators B: Chem., 2013, 185, 762-770

Multiwalled Carbon Nanotubes Modified by NTA-Copper Complex for Label-Free Electrochemical Immunosensor Detection. S. Chebil, N. Macauley, T. Hianik, H. Korri-Youssoufi, Electroanalysis, 2013, 25, 636-643

Binding kinetics of human cellular prion detection by DNA aptamers immobilized on a conducting polypyrrole. A. Miodek, A. Poturnayová, M. Snejdárková, T. Hianik, H. Korri-Youssoufi, Anal. Bioanal. Chem., 2013, 405, 2505-2514

Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum. S. B. Reeksting, I. B. Müller, P. B. Burger, E. S. Burgos, L. Salmon, A. I. Louw, L.-M. Birkholtz, C. Wrenger, Biochem. J., 2013, 449, 175-187

Photoassisted Generation of a Dinuclear Iron(III) Peroxo Species and Oxygen-Atom Transfer. F. Avenier, C. Herrero, W. Leibl, A. Desbois, R. Guillot, J.-P. Mahy, A. Aukauloo, Angew. Chem. Intern. Ed., 2013, 52, 3634-3637