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Institut de Chimie Moléculaire et des Matériaux d'Orsay

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Chimie Bioorganique et Bioinorganique

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Theme 2 (F. Avenier)

Design and synthesis of new metal complexes
and study of their interactions with biomolecules

F. Avenier, W. Ghattas, R. Ricoux

The activities developed in theme 2 build on the Group's internationally recognized know-how in Bioinorganic Chemistry for:

  • the development of biomimetic systems of heme metalloenzymes (hemoproteins: Cyt. P450, peroxidases ...) and non-heme metalloenzymes (hydroxylases mono- and bi-nuclear iron, methane monooxygenase ...), from transition metal complexes, metalloporphyrins or mono- or bi-metallic non-porphyrinic complexes,
  • the design of artificial metalloenzymes by insertion of metal complexes in various proteins according to three strategies: host-guest, Trojan and covalent attachment.

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The main objectives of the projects developed are the elaboration and mechanistic study of new selective and effective (bio)-catalysts that can be used under eco-compatible conditions (solvent = H2O, room temperature and pressure) and which have potential applications in fine chemistry, depollution, renewable energies and therapeutics / theranostics:

1- OXIDATION REACTIONS :
Iron mono-oxygenases biomimetic systems: Cytochromes P450 (P450), peroxydases et methane mono-oxygenase (MMO).

Objectives : Designing new complexes/biomimetic systems for:

A - Catalysing key reactions in various domains:
-Enantioselectives oxidations of substrats: sulfides, aromatics, alkenes usable in fine chemistry (production of metabolites),
-Oil chemistry : oxidation of hydrocarbons
-Depollution : oxidation of toxid dyes, oil pollutants(dibenzothiophene) and polyhalogenated aromatics.
1. Artificial metalloenzymes for enantioselective oxidation catalysis (xylanases, α-Rep, β-lactoglobuline)
R. Ricoux
2. Photocatalytic oxidations by artificial Ru-metalloenzymes
R. Ricoux
3. Bio-inspired oxidations catalysts for a more environmentally friendly chemistry
F. Avenier (ANR ARTENOSYN, labEx CHARM3AT)
4. Insertion of metalloenzymes into “Metal Organic Frameworks“ (MOF) : new catalysts for oxidative decontamination reactions
R. Ricoux (en collaboration avec Inst. Lavoisier Versailles, labEx CHARM3AT)

 

B - Performing oxidation of water:
-Decarbonated energies: production of new fuels

C - Elucidating some mechanistic aspects of 2-iron mono-oxygenases:

6. Synthesis of iron binuclear complexes for reductive activation of dioxygen: towards new bio-inspired oxidation catalysts
F. Avenier

 

2- ENANTIOSELECTIVE REACTIONS :

Objective: Developing new artificial complexes / biomimetic systems and metalloenzymes to catalyze enantioselective reactions for synthesis of:

- Hydrolysis ofphosphodiesters
- Diels-Alder et reductions
- Creation of C-C bond

7. Design of artificial metalloenzymes (Artzymes) for applications in enantioselective catalysis
R. Ricoux, W. Ghattas
8. Chemistry of creation of C-C bonds by radical SAM enzymes (artificial or not)
R. Ricoux, W. Ghattas, F. Avenier, J.-P. Mahy (ANR Carb2zyme 2017)
9. Design of tools for screening biocatalysts of bimolecular Diels-Alder reactions
W. Ghattas (en collaboration avec le Lab. COBRA, Rouen, labExes CHARM3AT et Synorg)

 

3-REACTIONS POUR LE DIAGNOSTIC ET LA THERAPIE :

Objectif : Préparer des enzymes artificielles ancrées à la surface de cellule vivantes, qui soient à termes utilisables pour catalyser in vivo la révélation de pro-drogues (thérapie) et/ou de pro-sondes (imagerie, diagnostic).