Institut de Chimie Moléculaire et des Matériaux d'Orsay

Zakaria Halime

Chargé de Recherche
Build. 420LCI – ICMMO
Université Paris-Sud
15, rue Georges Clémenceau
91405 Orsay Cedex
FRANCE

+33 1 69 15 47 56
zakaria.halime@u-psud.fr

Inorganic Chemisty Department

 

Artificial Photosynthesis Group

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Bibliography

Dr. Zakaria Halime received his PhD in chemistry from the University of Rennes 1, France, in 2006. After a postdoc experience in organic synthetic chemistry at the Institute of Organic Chemistry of Orléans (ICOA), France, he joined the group of Prof. Kenneth D. Karlin at Johns Hopkins University, Baltimore, USA, as a postdoctoral researcher for 3 years. During this period, he was also a Specially Appointed Assistant Professor in Osaka University (Prof. S. Fukuzumi research group), Japan, for few months. Dr. Halime returned to France in 2012 where he was first a research engineer in Brest University then the founder and the CEO of Easy Chelators company. In 2016, he was appointed a permanent position in the CNRS (the French National Research Agency) as a Senior Researcher (CR1).

Publications

33. Second sphere biomimetic multipoint hydrogen bonding patterns to boost CO2 reduction of iron porphyrins”

P. Gotico, B. Boitrel, R. Guillot, M. Sircoglou, A. Quaranta, Z. Halime, W. Leibl, A. Aukauloo Angewandte Chemie International Edition 2019, in press. DOI: 10.1002/anie.201804498

32. Design and Synthesis of Hybrid PEGylated Metal Monopicolinate Cyclam Ligands for Biomedical Applications”

F. Aouidat, Z. Halime, R. Moretta, I. Rea, S. Filosa, S. Donato, R. Tatè, L. De Stefano, R. Tripier, J. Spadavecchia, ACS Omega, 2019, 4, 2500.

31.  "Local ionic liquid environment at a modified iron porphyrin catalyst enhances the electrocatalytic performance of CO2 to CO reduction in water”

A. Khadhraoui, P. Gotico, B. Boitrel, W. Leibl, Z. Halime, A. Aukauloo, Chemical Communications 2018, 54 (82), 11630.

30. "Visible-Light-Driven Reduction of CO2 to CO and Its Subsequent Valorization in Carbonylation Chemistry and 13C Isotope Labeling”

P. Gotico, A. Del Vecchio, D. Audisio, A. Quaranta, Z. Halime, W. Leibl, A. Aukauloo, ChemPhotoChem 2018, 2 (8), 715.

29. "Water Molecules Gating a Photoinduced One-Electron Two-Protons Transfer in a Tyrosine/Histidine (Tyr/His) Model of Photosystem II”

G. Chararalambidis, S. Das, A. Trapali, A. Quaranta, M. Orio, Z. Halime, P. Fertey, R. Guillot, A. Coutsolelos, W. Leibl, A. Aukauloo, M. Sircoglou, Angewandte Chemie International Edition 2018, 57 (29), 9013.

28. "Comparison of Immuno-PET of CD138 and PET imaging with 64CuCl2 and 18F-FDG in a preclinical syngeneic model of multiple myelom”

C. Bailly, S. Gouard, M. Lacombe, P. Remaud-Le Saëc, B. Chalopin, M. Bourgeois, N. Chouin, R. Tripier, Z. Halime, F. Haddad, A. Faivre-Chauvet, F. Kraeber-Bodéré, M. Chérel, C. Bodet-Milin, Oncotarget, 2018, 9 (10), 9061.

27. "Light-Induced Activation of the Du Bois [RhII2(Esp)2] Catalyst for Nitrogen Atom Transfer Reactions”

R. Farran, C. Ducloiset, J. Buendia, N. T. Vo, R. Guillot, Z. Halime, P. Dauban, W. Leibl, M. Sircoglou, A. Aukauloo, ChemPhotoChem, 2017, 1 (12), 562.

26.  "Cyclams with Ambidentate Methylthiazolyl Pendants for Stable, Inert, and Selective Cu(II) Coordination "

A. Rodríguez-Rodríguez, Z. Halime, L. M. P. Lima, M. Beyler, D. Deniaud, N. Le Poul, R. Delgado, C. Platas-Iglesias, V. Patinec, R. Tripier, Inorganic Chemistry, 2016, 55 (2), 619.

25. "A [two-step/one week] synthesis of C-functionalized homocyclens and cyclams. Application to the preparation of conjugable BCAs without chelating properties alteration"

N. Camus, Z. Halime, N. Le Bris, H. Bernard, M. Beyler, C. Platas-Iglesias, R. Tripier, RSC Advances, 2015, 5, 85898.

24. "New synthesis of phenyl-isothiocyanate C-functionalised cyclams. Bioconjugation and 64Cu phenotypic PET imaging studies of multiple myeloma with the te2a derivative"

Z. Halime, M. Frindel, N. Camus, P. Y. Orain, M. Lacombe, M. Chérel,  J. F. Gestin, A. Faivre-Chauvet, R. Tripier, Organic & Biomolecular Chemistry, 2015, 13, 11302.

23. "Final step gallium-68 radiolabelling of silica coated iron oxide nanorods as potential MRI/PET dual imaging agents"

B. P. Burke, N. Baghdadi, G. S. Clemente, N. Camus, A. E. Kownacka, J. Domarkas, Z. Halime, R. Tripier, S. J. Archibald, Fraday Discussion, 2014, 175, 59.

22. "Monopicolinate Cross-bridged Cyclam Combining Very Fast Complexation with Very High Stability and Inertness of its Copper(II) Complex

L.M. P. Lima, Z. Halime, R. Marion, N. Camus, R. Delgado, C. Platas-Iglesias, R.Tripier, Inorganic Chemistry, 2014, 53, 5269.

21. "Full Control of the Regiospecific N-Functionalization of C-Functionalized Cyclam Bisaminal Derivatives and Application to the Synthesis of their TETA, TE2A, and CB-TE2A Analogues

N. Camus, Z. Halime, H. Bernard, N. Le Bris, C. Platas-Iglesias, R. Tripier, The Journal of Organic Chemistry, 2014, 79 (5), 1885.

20. Patent: "Picolinate Cross-Bridged Cyclam, Chelates with Metallic Cations and Use Therefor"

Z. Halime, R. Tripier, International patent, 2013, WO 2015071334 A1 20150521.

19.  "Spectroscopic Elucidation of a New Heme/Copper Dioxygen StructureType: Implications for O···O Bond Rupture in Cytochrome c Oxidase"

M. T. Kieber-Emmons, M. F. Qayyum, Y. Li, Z. Halime, K. O. Hodgson, B. Hedman, K. D. Karlin, E. I. Solomon, Angewandte Chemie International Edition, 2012, 51, 168.

18. Book chapter: Z. Halime, K. D. Karlin, "Cytochrome c Oxidase & Models", in Wiley Series on Reactive Intermediates in Chemistry and Biology, Vol. 5 (Series Ed.: S. E. Rokita), Copper-Oxygen Chemistry (Eds.: S. Itoh, K. D. Karlin), Wiley-VCH, Hoboken, 2011.

17. "Electronic Structure of a Low-Spin Heme/Cu Peroxide Complex: Spin-State and Spin-Topology Contributions to Reactivity"

M. T. Kieber-Emmons, Y. Li, Z. Halime, K. D. Karlin, E. I. Solomon, Inorganic Chemistry, 2011, 50, 11777.

16. "Dioxygen Reduction to Water by a Cytochrome c Oxidase Model, Insights into the Role of CuB"  

Z. Halime, H. Kotani, Y. Li, S. Fukuzumi, K. D. Karlin, Proceedings of the National Academy of Sciences, 2011, 108 (34), 13990.

15. "Functionalization of Porphyrins Towards the Synthesis of Bifunctional Chelates for Lead and Bismuth" Z. Halime, S. Balieu, B. Najjari, M. Lachkar, T. Roisnel, B. Boitrel, Journal of Porphyrins and Phthalocyanines, 2010, 14, 412.

14. "Heme-Copper/Dioxygen Complexes: Towards Understanding Ligand-Environmental Effects on Coordination Geometry, Electronic Structure and Reactivity"

Z. Halime, M. T. Kieber-Emmons, M. F. Qayyum, B. Mondal, S. M. Puiu, E. E. Chufán, A. Sarjeant, K. O. Hodgson, B. Hedman, E. I. Solomon, K. D. Karlin, Inorganic Chemistry, 2010, 49(8), 3629.

13. "Coordination of bismuth and lead in porphyrins: Towards an in-situ generator for α-radiotherapy?

Z. Halime, M. Lachkar, B. Boitrel, Biochimie, 2009, 91(10), 1318.

12. “Bismuth insertion in functionalized porphyrins: influence of the structure delivering substituted malonic acid groups"

S. Balieu, Z. Halime, M. Lachkar, B. Boitrel, Journal of Porphyrins and Phthalocyanines.  2008, 12, 1223.

11. "Coordination and structural studies of crowned-porphyrins"

Z. Halime, M. Lachkar, L. Toupet, A. G. Coutsolelos, B. Boitrel, J. Chem. Soc., Dalton Trans. 2007, 33, 3684.

10. Structural and Coordination Studies of Pearl Oysterlike Porphyrin”

Z. Halime, M. Lachkar, T. Roisnel, P. Richard, B. Boitrel, Inorganic Chemistry, 2007, 46, 6338.

9. " Bismuth and lead hanging-carboxylate porphyrins: an unexpected homobimetallic lead(II) complex "

Z. Halime, M. Lachkar, T. Roisnel, J. F. Halet, B. Boitrel, Angewandte Chemie International Edition, 2007, 46, 5120.

8. "The coordination of bismuth by porphyrins"

B. Boitrel, Z. Halime, S. Balieu, M. Lachkar, Comptes Rendus de l’Académie des Sciences. Série II. Chimie, 2007, 10, 583.

7. "Pre-shaped aromatic picket porphyrins bearing neutral oxygen donors and their bismuth complexes: Synthesis and Coordination Studies"

M. Michaudet, Z. Halime, M. Lachkar, B. Boitrel, Letters in Organic Chemistry, 2006, 3, 753.

6. " Linear and pre-organized carboxylic acid picket porphyrins as bismuth chelator "  

Z. Halime, M. Lachkar, E. Furet, J. F. Halet, B. Boitrel, Inorganic Chemistry, 2006, 45, 10661.

5. "Novel crowned-porphyrin ligands. Synthesis and conformational studies"

Z. Halime, M. Lachkar, N. Matsouki, G. Charalambidis, M. Vaira, G. Coutsolelos, B. Boitrel, Tetrahedron, 2006, 13, 3056.

4. "Functionalization of porphyrins: Mechanistic Insights, Conformational Studies and Structural Characterisations"

Z. Halime, S. Balieu, M. Lachkar, T. Roisnel, P. Richard, B. Boitrel, European Journal of Organic Chemistry, 2006, 5, 1207.

3. "Influence of pendant arms bearing ligating groups on the structure of bismuth porphyrins: Implications for labeling immunoglobulins used in medical applications"

Z. Halime, L. Michaudet, M. Lachkar, P. Brossier, B. Boitrel, Bioconjugate Chemistry, 2004, 15, 1193.

2. "Structural characterisation of the first mononuclear bismuth porphyrin"

B. Boitrel, Z. Halime, L. Michaudet, M. Lachkar, L. Toupet, Chemical Communications, 2003, 2670.

1. "Synthesis, characterisation, and properties of bismuth(III) ester pendant arms picket porphyrins"

Z. Halime, M. Razavet, L. Michaudet, C. Ruzie, B. Boitrel, J. Chem. Soc., Dalton Trans, 2003, 22, 4250.

Second-Sphere Biomimetic Multipoint Hydrogen-Bonding Patterns to Boost CO2 Reduction of Iron Porphyrins. P. Gotico, B. Boitrel, R. Guillot, M. Sircoglou, A. Quaranta, Z. Halime, W. Leibl, A. Aukauloo, Angewandte Chemie International Edition, 2019, 58, 4504-4509

Local ionic liquid environment at a modified iron porphyrin catalyst enhances the electrocatalytic performance of CO2 to CO reduction in water. A. Khadhraoui, P. Gotico, B. Boitrel, W. Leibl, Z. Halime, A. Aukauloo, Chem. Commun., 2018, 54, 11630-11633

Visible Light-Driven Reduction of CO2 to CO and Its Subsequent Valorization in Carbonylation Chemistry and 13C Isotope Labelling. P. Gotico, A. Del Vecchio, D. Audisio, A. Quaranta, Z. Halime, W. Leibl, A. Aukauloo, ChemPhotoChem, 2018, 2, 715-719

Water Molecules Gating a Photoinduced One Electron Two Protons Transfer in a Tyr/His model of Photosystem II. G. Chararalambidis, S. Das, A. Trapali, A. Quaranta, M. Orio, Z. Halime, P. Fertey, R. Guillot, C. Athanassios, W. Leibl, A. Aukauloo, M. Sircoglou, Angew. Chem. Int. Ed., 2018, 57, 9013-9017

Light-Induced Activation of the Du Bois [RhII2(Esp)2] Catalyst for Nitrogen Atom Transfer Reactions. R. Farran, C. Ducloiset, J. Buendia, N. T. Vo, R. Guillot, Z. Halime, P. Dauban, W. Leibl, M. Sircoglou, A. Aukauloo, ChemPhotoChem, 2017, 1, 562-567