Institut de Chimie Moléculaire et des Matériaux d'Orsay

Presentation of the ICMMO

 


The independent scientific teams, conduct their research according to their areas of expertise. However, all activities will grow by 4 axis transverse to combine basic research and applications beneficial to society:

  1. Chemistry and Health
  2. Energy
  3. Information
  4. Environment 

Chemistry and Health

» Coordinnator: David Bonnaffé

» Groups mobilized on that topic:
       Synthèse Organique et Méthodologie
       Procédés et Substances Naturelles
       Catalyse Moléculaire
       Chimie Bioorganique et Bioinorganique
       Glycochimie Moléculaire et Macromoléculaire
       RMN en milieu orienté

The ICMMO has all the expertise necessary to develop methods by original target of enantiomerically pure molecules and analyzing their interaction with biomolecules. Understanding these interactions enzyme / substrate protein / sugar or protein / protein is the basis for the development of future drugs. Organic chemistry and methodology, control of chirality, chemistry of sugars and metal complexes. As many know-how possessed by researchers ICMMO, without forgetting the detection of chirality by NMR, which will play a synergistic role for drug development, métallodrogues, biosensors, artificial enzymes ... the role of chemists in steps to move from a "key" to a "seeded" (optimizing molecular testing in vitro, in cellular and in vivo) and its application in molecular form (prodrugs, vectorization, chip preparation and biosensors), will be an apparent centrality of research developed in the coming years. And will be favored in the years to come.

The synthesis of new molecules, total synthesis of biologically active molecules (oligosaccharides, alkaloids and analogues), prepared by means original (enantioselective catalysis, memory of chirality, photochemistry ...) of non-natural amino acids, rational design or optimization of molecular ' inhibitors or protein ligands (new anti-inflammatory glycoconjugate, sugar-chimera protein targeting HIV), use of dynamic combinatorial chemistry, or classical, and preparation of nanoparticles with surfaces combinatorial identify new structures with a modulating activity of 'spindle assembly or tubulin migration of metastases.

Formatting molecules represent axis of very active research: surface modification by molecules to make them bioactive, or to develop diagnostic tools (detection of thrombosis, and viral ...), targeting of active coupling with mimics of RGD or oligosaccharides, preparation of prodrugs, multivalent presentation of oligosaccharide compounds to potentiate their effect.
Finally, the development of new methods for imaging cellular or molecular clock control of cellular aging will provide new avenues for original research, and the constant development of new analysis of NMR-oriented environment.

Chemistry and Energy

» Coordinnator: Pierre Millet

» Equipes mobilisées sur ce thème :
       Glycochimie Moléculaire et Macromoléculaire
       Chimie inorganique
       Etude des Matériaux Hors Equilibre
       Physicochimie de l’Etat Solide

Again, the ICMMO has, through the teams mentioned above, a number of expertise that allow to think that he can participate extremely important to solve a problem that is becoming more crucial for our society: energy. The ICMMO think even create progressively, as will be discussed later, a team focused on this theme. For now, the four main aspects mingle harmoniously developed academic research and applied research and will be supported through contracts (EU, ANR, industrial) that will finance dissertations and postdoctoral positions.

Hydrogen energy carrier
The research developed on the theme "hydrogen energy" for (i) hydrogen production by electrolysis of water, (ii) purification by gas permeation through metallic membranes, (iii) storage, transport and distribution of hydrogen as metal hydrides, (iv) co-generation heat and electricity using fuel cells H2/O2 (v) systems electrolyser stack-reversible.

Photo-electrochemistry, photo-fuels
The research developed on the theme "photo-electrochemistry, photo-fuels" for (i) development of modules for the catalytic oxidation of water, reduction of protons and CO2 reduction, (ii) techniques assembly of modules for the development of photoactive molecular devices, (iii) the study of photophysical properties (joint CEA Team - UPS), (iv) development of new electrodes for the Electrolysis of Water Photo-assisted .

Transport and storage of electrical energy
Research on superconducting oxides at high temperature are critical objectives (i) a better understanding of the underlying physics from the study of crystals, (ii) optimizing composite alloy / oxide. The research developed on the theme "lithium battery" for (i) the synthesis of new intercalation materials, (ii) their structural and electrochemical characterization, (iii) the characterization of lithium-ion batteries for industrial interest.

New structural materials
The proposed studies focus on the mechanical and microstructural characterization of alloys and lightweight composite materials for reducing the energy needs of transportation. They also cover new assembly techniques for these materials. New alloys for nuclear 4th generation are also developing.

Chemistry and Information

» Coordinnator: Bertrand Poumellec

» Groups mobilized on that topic:
       Procédés et Substances Naturelles
       Catalyse Moléculaire
       Chimie Bioorganique et Bioinorganique
       Glycochimie Moléculaire et Macromoléculaire
       Chimie Inorganique
       Etude des Matériaux Hors Equilibre
       Physico-Chimie de l’Etat Solide

Information has become a multidisciplinary field, involving the following string: detectors (physical properties, chemical and biological), local routing information (physical and material sciences), processing this information (optical, mathematical), transport (optical, chemical materials), distribution (optical), interfacing with the user (display, ergonomic, biological chemistry, organic transduction) and finally storage.
It is thus that the axis brings together information to ICMMO for over 15 years of expertise in many of these disciplines: control of properties of molecules and magnetic solids or multiferroic, molecular interactions, control of the laser-glass and finally the simulation. The axis information is an important focus for the Institute. It gives rise to research among the best internationally and is the 1st axis in financial terms with basic activities to intensive recoverable in the short term (European contracts (5), ANR (6) and industrial). Its activity will intensify in the next four as well to improve information systems for its treatment in the field of sound, of course, but also in the field of life sciences, the living species constituting systems of 'the most developed information that we know. Thus, we observed a rise in several areas: the compute-intensive with a very important development of the project equipment CINAPS, nanomachines, activities based on sugar, or the laser-lens assembly with a femtosecond laser platform in conjunction with the General Council of Essonne.

Some activities will be financed under the RTRA Triangle of physics: nano-triggerable switches to the light in collaboration with CEA, 3D registration in connection with the group Manolya (Roosen) functionalization of metal with group MaCSyBio Materials, Components and Systems for Biophotonics Laboratory Charles Fabry de L'Institut d'Optique, functionalization of surfaces for the detection of information with the Laboratory of Atomic and Molecular Collisions (UPS) and the team of SPCSI DRECAM CEA.

Collaborations will be developed under the ESRP UniverSud Paris: The team of inorganic chemistry with the University Versailles Saint Quentin (group of molecular solids photoswitches), the team of Physical Chemistry of Solid State with the group mechanics Materials and Structures for Structural Design of refractive index recorded by laser in silica glass. The team Glycochemistry Molecular and Macromolecular lead a joint project with the Task of Assembling Molecular Thiais for molecular recognition, door selection information.

The ICMMO also benefit from international collaboration through European contracts such as the project SOPRANO (Spin and Orbital Physics: research of advanced oxides, ITN Marie Curie) or the extension of project FLAG (Femtosecond Laser Applications in Glasses, FET -STREP).
Collaborations with the LCP should be developed in the field of nanosciences and Chemistry in the calculation, including the development of quantum computers or massively parallel. The expertise available in ICMMO expected on some points (control of asymmetric synthesis and pulsed lasers) to be useful and exploited fruitfully in collaborations between the two Institutes. Finally, dynamic combinatorial chemistry developed in recent years in ICMMO should be harnessed in the development of biological computers. Indeed, in this case, we seek to realize a number of reactions from one hand, products that encode the initial conditions and on the other hand, catalysts or inhibitors that encode the computational.

Chemistry and Environment

» Coordinnator: Marie-Christine Scherrmann

» Groups mobilized on that topic:
       Procédés et Substances Naturelles
       Catalyse Moléculaire
       Chimie Bioorganique et Bioinorganique
       Glycochimie Moléculaire et Macromoléculaire
       Chimie Inorganique
       Physico-Chimie de l’Etat Solide

Having appointed in June 2008 on a new teacher profile "green chemistry" (Marie Christine Scherrmann), the ICMMO engage resolutely in the next four on the way of chemistry "environmentally friendly". This will include various aspects mentioned below:

Renewable energy: these activities overlap with the previous theme and will include production of hydrogen by electrolysis of water and storage (P. MILLET) and research on artificial photosynthesis under the leadership of A. AUKAULOO.

The development of new synthetic methods incorporating the principles of green chemistry. Several strategies will be developed in the sense of a gradual and steady evolution towards cleaner processes such as molecular catalysis: use of enantioselective metal catalysts, biocatalysis (the use of enzymes in synthesis, bioconversion): metalloproteins artificial oxidation selective organic molecules (JP Mahy), use of enzymes for the synthesis of oligosaccharides and sugars modified by sulfotransferases (C. THE NARVOR), the use of chiral ionic liquid produced from natural sources from the sugar industry and chemistry under microwave (Vo Than Giang), chemistry supported aqueous phase (Mark Scherrmann)

Remediation: the treatment of industrial water effluents and particularly the oxidative degradation of chlorophenols be pursued by means of enzyme (peroxidase encapsulated in polymeric maricas Mr. THERISOD) or catalytic (metal complex bio-inspired, F. BANSE).