Institut de Chimie Moléculaire et des Matériaux d'Orsay

Méthodologie, Synthèse et Molécules Thérapeutiques - MSMT

Pauline presents her PhD research project in 3 minutes. Recorded at the ACS meeting in San Diego in March 2016. [Click here]

Strategies for the Synthesis of α- and β-Amino Vinylphosphonates

Adler, P.; Fadel, A.; Rabasso, N. Tetrahedron 2014, 70, 4437-4456 [PDF]

Cerium(IV) ammonium nitrate mediated 5-endo-dig cyclization of α-amino allenylphosphonates to spirodienones

Adler, P.; Fadel, A.; Rabasso, N. Chem. Commun. 2015, 51, 3612-3615 [DOI]

Regioselective Hydroarylation Reactions of C3 Electrophilic N-Acetyl Indoles activated by FeCl3. An Entry into 3-(Hetero)Aryl Indolines

Beaud, R.; Guillot, R.; Kouklovsky, C.; Vincent, G. Chem. Eur. J. 2014, 20, 7492-7500.

The quest of an oxidative coupling of phenols and indoles towards benzofuroindolines: a two stage approach

Beaud R.; Tomakinian T.; Denizot N.; Pouilhès A.; Kouklovsky C.; Vincent G. Synlett 2015, DOI: 10.1055/s-0034-1379495

Direct Oxidative Coupling of N-Acetyl Indoles and Phenols for the Synthesis of Benzofuroindolines Related to Phalarine

Tomakinian, T.; Guillot, R.; Kouklovsky, C.; Vincent, G. Angew. Chem. Int. Ed. 2014, 53, 11881-11885.

Bioinspired Direct Access to Benzofuroindolines by Oxidative [3 + 2] Annulation of Phenols and Indoles

Denizot, N.; Pouilhes, A.; Cucca, M., Beaud, R.; Guillo,t R.; Kouklovsky, C. Vincent, G. Org. Lett. 2014, 16, 5752-5755

Methodology

Syntheses

Therapeutic Molecules

Our team is developping original and robust synthetic methods to be applied in the synthesis of bioactive compounds. An important feature is the selectivity of chemical transformations (chemoselectivity and stereoselectivity) to access nitrogen, oxygen or phosphorus containg compounds.

Our team is developping numerous total syntheses of bioactive natural products an their analogues. Our goal is to integrate molecular diversity in our syntheses, especially in the field of alkaloid, aminoacids and oligosaccharide synthesis

As a tool for therapeutic innovation, we aim to apply the concept of molecular diversity to the design and synthesis of bioactive compounds. We have already obtained significant results for the preparation of antiviral, antitumoral and antibiotic compounds.