Institut de Chimie Moléculaire et des Matériaux d'Orsay

Méthodologie, Synthèse et Molécules Thérapeutiques - MSMT

Les publications de l'équipe

Notre équipe, créée au 1er janvier 2014, est née de l'association de plusieurs chercheurs provenant de différentes équipes de l'ICMMO. Pour consulter notre production scientifique depuis au 1er janvier 2014, cliquer ici.

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006


    • " p-Methoxybenzyl-N-phenyl-2,2,2-Trifluoroacetimidate: a Versatile Reagent For Mild Acid catalyzed Etherification " Barroca-Aubry Nadine, Benchekroun Mohamed, Gomes Filipe, Bonnaffé David Tetrahedron Lett. 2013, 54, 5118-5121
    • " Stereodivergent synthesis of piperidine alkaloids by ring-rearrangement metathesis/reductive lactam alkylation of nitroso-Diels-Alder cycloadducts " Vincent Guillaume, Karila Delphine , Khalil Georges, Sancibrao Pierre, Gori Didier, Kouklovsky Cyrille Chem. Eur. J. 2013, 19, 9358-9365 [PDF]
    • " Stereoselective Synthesis of Oxaspirannic Building Blocks by Regioselective Nitroso Diels-Alder Reaction " Sancibrao Pierre, Gori Didier, Kouklovsky Cyrille, Vincent Guillaume Chem. Eur. J. 2013, 19, 5557-5560 [PDF]
    • " Selective Reduction of Amino Allenephosphonates: Preparation of α-Amino Vinylphosphonates " Adler Pauline, Gomes Filipe, Fadel Antoine, Rabasso Nicolas Eur. J. Org. Chem. 2013, 7546-7555 [PDF]
    • " Asymmetric Sharpless Dihydroxylation Reaction of Chiral Bishomoallylic Alcohols: Application to the Synthesis of the C1-C10-C5 Fragment of FR225654 " Mohammad Shabbair , Dhambri Sabrina , Gori Didier, Vaxelaire Carine , Sorin Geoffroy , Ardisson Janick , Lannou Marie-Isabelle Synlett 2013, 24, [PDF]
    • " An Approach to the Synthesis of Tetrahydroisoquinoline Alkaloids by Alkene Hydroamination: Synthesis of Coralydine " Pouilhes Annie, Baltaze Jean-Pierre, Kouklovsky Cyrille Synlett 2013, 24, 1805-1808 [PDF]
    • " Regio- and Stereochemical Studies on the Nitroso Diels-Alder Reaction with1,2-Disubstituted Dienes " Galvani Gilles, Lett Robert, Kouklovsky Cyrille Chem. Eur. J. 2013, 19, 15604 [PDF]


    • " Constrained alpha/gamma-peptides: a new stable extended structure in solution without any hydrogen bond and characterized by a four-fold symmetry " Bouillère Francelin, Feytens Debby, Gori Didier, Guillot Régis, Miclet Emeric, Kouklovsky Cyrille, Alezra Valérie Chem. Commun. 2012, 48, 1982-1984 [PDF]
    • " Original β,γ-diamino acid as an inducer of a γ-turn mimic in short peptides " Thétiot-Laurent Sophie, Bouillère Francelin, Baltaze Jean-Pierre, Brisset François, Feytens Debby, Kouklovsky Cyrille, Miclet Emeric, Alezra Valérie Org. Biomol. Chem. 2012, 10, 9660-9663 [PDF]
    • " Absolute Asymmetric Synthesis of Tertiary alpha-Amino Acids " Mai Thi Thoa, Branca Mathieu, Gori Didier, Guillot Régis, Kouklovsky Cyrille, Alezra Valérie Angew. Chem. Int. Ed. 2012, 51, 4981-4984 [PDF]
    • " [2,3]-Sigmatropic Rearrangement of Ynamides: Preparation of α-Amino Allenephosphonates " Gomes Filipe, Fadel Antoine, Rabasso Nicolas J. Org. Chem. 2012, 77, 5439-5444 [PDF]
    • " 1-Aminocyclopropane-1-carboxylic acid oxidase: insight into cofactor binding from experimental and theoretical studies " Brisson Lydie, El Bakkali-Taheri Nadia, Giorgi Michel, Fadel Antoine, Kaizer Jozsef, Réglier Marius, Tron Thierry, Ajandouz El Hassan , Simaan A. Jalila J. Biol. Inorg. Chem. 2012, 17, 939-949 [PDF]
    • " One-pot formation of aza-enolates from secondary amines and condensation to esters and alkyl bromides " Chevalley Alice, Férézou Jean-Pierre Tetrahedron 2012, 68, 5882-5889 [PDF]
    • " Memory of Chirality of Tertiary Aromatic Amide: Application to the Asymmetric Synthesis of (S)‑α-MethylDOPA " Mai Thi Thoa, Viswambharan baby, Gori Didier, Kouklovsky Cyrille, Alezra Valérie J. Org. Chem. 2012, 77, 8797–8801 [PDF]
    • " Continuous Evolution Profiles for Electronic-Tongue-Based Analysis " Hou Yanxia, Genua Maria, Tada Batista Dayane, Calemczuk Roberto, Buhot Arnaud, Fornarelli Pauline, Koubachi Jamal, Bonnaffé David, Saesen Els, Laguri Cédric, Lortat-Jacob Hugues, Livache Thierry Angewandte Chemie International Edition 2012, 51, 10394-10398 [PDF]
    • " Chondroitin-4-O-sulfatase from Bacteroides thetaiotaomicron: exploration of the substrate specificity " Malleron Annie, Benjdia Alhosna, Berteau Olivier, Le Narvor Christine Carbohydrate Res. 2012, 353, 96-99 [PDF]
    • " Asymmetric synthesis of a higly functionalized enantioenriched system close to thapsigargin framework " Tap Aurélin, Jouanneau Morgan, Galvani Gilles, Sorin Geoffroy, Lannou Marie-Isabelle, Férézou Jean-Pierre, Ardisson Janick Org. Biomol. Chem. 2012, 10, 8140-8146 [PDF]
    • " FeCl3-Mediated Friedel–Crafts Hydroarylation with Electrophilic N-Acetyl Indoles for the Synthesis of Benzofuroindolines " Beaud Rodolphe, Guillot Régis, Kouklovsky Cyrille, Vincent Guillaume Angew. Chem. Int. Ed. 2012, 51, 12546-12550 [PDF]
    • " Flavonoids from Mimosa xanthocentra (Leguminosae: Mimosoideae) and molecular modeling studies for Isovitexin−2"−O−alpha−L−rhamnopyranoside rotamers " De Magalhães Camargo Luiza Maria, Férézou Jean-Pierre, Wanderley Tinoco Luzineide, Kaiser Carlos Roland, Soares Costa Sônia Phytochem. Lett. 2012, 5, 427−431 [PDF]
    • " A synthetic heparan sulfate-mimetic peptide conjugated to a mini CD4 displays very high anti-HIV-1 activity independently of coreceptor usage. " Connell Bridget J., Baleux Françoise, Coic Yves-Marie, Clayette Pascal, Bonnaffé David, Lortat-Jacob Hugues Chem. Biol. 2012, 19, 131-139
    • " Quels sont les apports potentiels de la plate-forme WIMS ? Application à l’enseignement de la chimie " Duffault Jean-Marc, Rabasso Nicolas, Ramage Marie-Joëlle L'Actualité Chimique 2012, Mai 2012, 47-50


    • " Synthesis of an enkephalin analogue containing an α,α-disubstituted heterocyclic aminophosphonic acid " Rabasso Nicolas, Fadel Antoine Phosphorus, Sulfur Silicon Relat. Elem. 2011, 186, 1811-1819 [PDF]
    • " Bioactive synthetic Heparan Sulfate and Heparin derivatives: from long fragments mimetics to chimeras " Bonnaffé David Comptes Rendus Chimie 2011, 14, 59-73 [PDF]
    • " Access to beta,gamma-diamino acids. Application to the synthesis of 3-deoxyaminostatine " Bouillère Francelin, Guillot Régis, Kouklovsky Cyrille, Alezra Valérie Org. Biomol. Chem. 2011, 9, 394-399 [PDF]
    • " Stereodivergent Synthesis of Substituted N,O-Containing Bicyclic Compounds by Sequential Addition of Nucleophiles to N-Alkoxybicyclolactams " Vincent Guillaume, Guillot Régis, Kouklovsky Cyrille Angew. Chem. Int. Ed. 2011, 50, 1350 –1353 [PDF]
    • " Highly Regio- and Stereoselective Nickel-Catalyzed Addition of Dialkyl Phosphites to Ynamides: an Efficient Synthesis of β-Aminovinylphosphonates " Fadel Antoine, Legrand Frédéric, Evano Gwilherm, Rabasso Nicolas Adv. Synth. Catal. 2011, 353, 263-267 [PDF]
    • " Enantioselective Intramolecular Hydroamination of Secondary Amines Catalyzed by Easily Accessible Ate and Neutral Rare-Earth Complexes " Queffelec Clémence, Boeda Fabien, Pouilhes Annie, Meddour Abdelkrim, Kouklovsky Cyrille, Hannedouche Jérôme, Collin Jacqueline, Schulz Emmanuelle ChemCatChem 2011, 3, 122-126
    • " Ring-rearrangement metathesis of Nitroso Diels-Alder cycloadducts " Vincent Guillaume, Kouklovsky Cyrille Chem. Eur. J. 2011, 17, 2972-2980 [PDF]
    • " Foldamers containing gamma-amino acid residues or their analogues: structural features and applications " Bouillère Francelin, Thétiot-Laurent Sophie, Kouklovsky Cyrille, Alezra Valérie Amino Acids 2011, 41, 687-707 [PDF]
    • " Vous prendrez bien un peu de sucre ? " Barroca-Aubry Nadine, Beau Jean-Marie, Bonnaffé David, Bourdreux Yann, Doisneau Gilles, Le Narvor Christine, Lepoittevin Bénédicte, Roger Philippe, Urban Dominique, Vauzeilles Boris Plein Sud 2011, Spécial Recherche 2010/2011, 104-115 [PDF]
    • " Sequential Addition of Nucleophiles to Bicyclic isoxazolactams " Vincent Guillaume, Guillot Régis, Kouklovsky Cyrille Synfacts 2011, 4, 418 [PDF]
    • " Terpenic sub−fraction of Pterodon Pubescens induces apoptosis of K562 leukemic cells by modulating gene expression " Pereira Monica Farah, Martino Thiago, Ranto Dalmau Sergio, Mattos Albano Rodolfo, Férézou Jean-Pierre, Soares Costa Sônia, Garcia Pinto Coelho Marsen, Gosta Carvalho Sabino Kátia Oncology Reports 2011, 25, 215−221 [PDF]
    • " 2,3-Ivermectin ethyl secoester, a conjugated ivermectin derivative with leishmanicidal activity but without inhibitory effect on mammalian P-type ATPases " Noël François, Pimenta Paulo Henrique Cotrim, dos Santos Anderson Rouge, Tomaz Erick Carlos Loureiro, Quintas Luis Eduardo Menezes, Kaiser Carlos Roland, Silva Claudia Lucia Martins, Férézou Jean-Pierre Naunyn-Schmied Arch. Pharmacol. 2011, 383, 101-107 [PDF]


    • "Synthesis of new β- and γ-aminopyrrolidinephosphonates via 1,3-dipolar cycloaddition of substituted vinylphosphonates" Rabasso Nicolas, Fadel Antoine Tetrahedron Lett. 2010, 51, 60-63 [PDF]
    • " HABA-based ionic liquid matrices for UV-MALDI-MS analysis of heparin and heparan sulfate oligosaccharide " Cedric Przybylski, Florence Gonnet, Bonnaffé David, Hersant Yaël, Hugues Lortat-Jacob, Regis Daniel Glycobiology 2010, 20, 224-234
    • " Desorption Electrospray Ionization Mass Spectrometry of Glycosaminoglycans and Their Protein Noncovalent Complex" Przybylski Cédric, Gonnet Florence, Hersant Yaël, Bonnaffé David, Lortat-Jacob Hugues, Daniel Régis Analytical Chemistry 2010, 82, 9225-9233 [PDF]
    • " Oxidation of organic molecules in homogeneous aqueous solution catalyzed by hybrid biocatalysts (based on the Trojan Horse strategy). " Sansiaume Elodie, Ricoux Rémy, Gori Didier, Mahy Jean-Pierre Tetrahedron: Asym 2010, 21, 1593-1600 [PDF]
    • " Synthetic Approaches to Racemic Porantheridine and 8-Epihalosaline via a Nitroso Diels-Alder Cycloaddition/ Ring Rearrangement Metathesis Sequence " Sancibrao Pierre, Karila Delphine, Kouklovsky Cyrille, Vincent Guillaume J. Org. Chem. 2010, 75, 4333-4336 [PDF]
    • " Surface characterizations of poly(ethylene terephthalate) film modified by a carbohydrate-bearing photoreactive azide group " Roger Philippe, Laëtitia Renaudie, Le Narvor Christine, Lepoittevin Bénédicte, Loïc Bech, Maurice Brogly European Polymer Journal 2010, 46, 1594–1603
    • " New chiral amino acid-derived α-acyloxynitroso reagents for asymmetric nitroso Diels–Alder reactions " Li Hailing, Gori Didier, Kouklovsky Cyrille, Vincent Guillaume Tetrahedron: Asym. 2010, 21, 1507-15010 [PDF]
    • " Copper-Free Click Chemistry for Highly Luminescent Quantum Dot Conjugates: Application to in Vivo Metabolic Imaging " Bernardin Aude, Cazet Aurélie, Guyon Laurent, Delannoy Philippe, Vinet Françoise, Bonnaffé David, Texier Isabelle Bioconjugate Chemistry 2010, 21, 583-588 [PDF]
    • " Hijacking of the Pleiotropic Cytokine Interferon-gamma by the Type III Secretion System of Yersinia pestis " Gendrin Claire, Sarrazin Stéphane, Bonnaffé David, Jault Jean-Michel, Lortat-Jacob Hugues, Dessen Andréa PLoS one 2010, 5, e15242 [PDF]
    • " Ytterbium Trifluoromethansulfonate" Tran Anh Tuan, Bonnaffé David Synlett 2010, 1880-1881 [PDF]
    • " Alpha-acyloxynitroso Dienophiles in [4+2] Hetero Diels-Alder Cycloadditions: Mechanistic Insights " Calvet Géraldine, Coote Susannah C., Blanchard Nicolas, Kouklovsky Cyrille Tetrahedron 2010, 66, 2969-2980 [PDF]


    • " Aminoacid homologation by the Blaise reaction: a new entry into nitrogen heterocycles " Hoang Cam Thuy, Bouillère Francelin, Johannesen Sine, Zulauf Anais, Panel Cecilia, Gori Didier, Pouilhes Annie, Alezra Valérie, Kouklovsky Cyrille J. Org. Chem. 2009, 74, 4177-4187 [PDF]
    • " Memory of Chirality of Tertiary Aromatic Amides: a Simple and Efficient Method for the Enantioselective Synthesis of Quaternary alpha-Amino Acids " Branca Mathieu, Pena Sébastien, Gori Didier, Guillot Régis, Alezra Valérie, Kouklovsky Cyrille J. Am. Chem. Soc. 2009, 131, 10711-10718 [PDF]
    • " Highly stereoselective synthesis of new α-amino-β-hydroxy six-membered heterocyclic phosphonic acid, Serine analogues " Louaisil Nicolas, Rabasso Nicolas, Fadel Antoine Tetrahedron 2009, 65, 8587-8595 [PDF]
    • " A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry " Françoise Baleux, Latino Loureiro-Morais, Hersant Yaël, Pascal Clayette, Fernando Arenzana-Seisdedos, Bonnaffé David, Hugues Lortat-Jacob Nature Chemical Biology 2009, 5 (10), 743-748
    • " Camphor Derivatives in Asymmetric Cycloadditions and Rearrangements " Langlois Yves, Kouklovsky Cyrille Synlett 2009, 3065-3081 [PDF]


    • " Accurate conformation analysis in solution: NMR and DFT/PCM study of the S-3-(1-naphthoyl)-4-isopropyl-2,2-dimethyloxazolidin-5-one in CDCl3 " Branca Mathieu, Alezra Valérie, Kouklovsky Cyrille, Archirel Pierre Tetrahedron 2008, 64, 1743-1752 [PDF]
    • " 3-aminopyrrolidines from a-amino acids: total synthesis of (+)-nemonapride from D-alanine " Cam Thuy Hoang, Viet Hoang Nguyen, Alezra Valérie, Kouklovsky Cyrille J. Org. Chem. 2008, 73, 1162-1164 [PDF]
    • " Efficient cleavage of the N-O bond of 3,6-dihydro-1,2-oxazines mediated by some alpha-hetero substituted carbonyl compounds in mild conditions " Galvani Gilles, Calvet Géraldine, Blanchard Nicolas, Kouklovsky Cyrille Org. Biomol. Chem. 2008, 6, 1063-1070 [PDF]
    • " Chemo-enzymatic supported synthesis of the 3-sulfated Lewisa pentasaccharide on a multimeric polyethylene glycol " Malleron Annie, Le Narvor Christine Carbohydr. Res. 2008, 343, 970-976 [PDF]
    • "  Regioselective green anomeric deacetylation catalyzed by lanthanide triflates " Tran Anh Tuan, Deydier Sophie, Bonnaffé David, Le Narvor Christine Tetrahedron Lett. 2008, 49, 2163-2165 [PDF]
    • " Mixture Synthesis and "Charge Tagging" Based Demixing: An Efficient Strategy for the Preparation of Heparan Sulfate Libraries " Anna Dilhas, Ricardo Lucas, Latino Loureiro-Morais, Hersant Yaël, Bonnaffé David J. Comb. Chem. 2008, 10, 166–169 [PDF]
    • " Enantioselective total synthesis of pyrinodemin A " Pouilhes Annie, Florès Anel, Vidal Anne, Langlois Yves, Kouklovsky Cyrille Org. Biomol. Chem. 2008, 6, 1502-1510 [PDF]
    • " Tertiary Aromatic Amide for Memory of Chirality: Access to Enantioenriched alpha-Substituted Valine " Branca Mathieu, Gori Didier, Guillot Régis, Alezra Valérie, Kouklovsky Cyrille J. Am. Chem. Soc. 2008, 130, 5864-5865 [PDF]
    • "Synthesis of New (3-Aminopyrrolidin-3-yl)phosphonic Acid – A Cucurbitine Analogue – and (3-Aminotetrahydrothiophen-3-yl)phosphonic Acid via Phosphite Addition to Heterocyclic Hydrazones" Rabasso Nicolas, Fadel Antoine Synthesis 2008, 2353-2362 [PDF]
    • "First synthesis of enantiomerically pure (1S,2S)- and (1R,2R)-1,2-diaminocyclobutanecarboxylic acid–ornithine derivative–, from racemic 2-aminocyclobutanone" Hazelard Damien, Fadel Antoine, Guillot Régis Tetrahedron: Asymmetry 2008, 19/17, 2063-2067 [PDF]
    • " Synthesis and Biological Evaluation of Bengacarboline Derivatives " Pouilhes Annie, Kouklovsky Cyrille, Langlois Yves, Baltaze Jean-Pierre, Vispé S., Annereau J.-P., Barret J.-M. , Kruczynski A., Bailly C. Bioorg. Med. Chem. Lett. 2008, 18, 1212-1216 [PDF]
    • " Camphor-derived sulfonylhydrazines: catalysts for Diels-Alder cycloadditions. " Langlois Yves, Petit Alain, Remy Pauline, Scherrmann Marie-Christine, Kouklovsky Cyrille Tetrahedron Lett. 2008, 49, 5576-5579 [PDF]
    • " Enantioselective Synthesis of Quaternary L-Valine Derivatives " Branca Mathieu, Gori Didier, Guillot Régis, Alezra Valérie, Kouklovsky Cyrille Synfacts 2008, 731


    • "Asymmetric Synthesis of (R)- and (S)-Amino-3-piperidinyl-phosphonic Acids via Phosphite Addition to Iminium Ions." Louaisil Nicolas, Rabasso Nicolas, Fadel Antoine Synthesis 2007, 289-293 [PDF]
    • "Functionalization of PET fibres by photografting of a carbohydrate derivatized with a phenyl azide group." Laëtitia Renaudie, Le Narvor Christine, Emmanuel Lepleux, Roger Philippe Biomacromolecules 2007, 8(2), 679-685 [PDF]
    • "An efficient synthesis of enantiomerically pure (R)-pipecolic acid, (S)-proline and their N-alkylated derivatives." Lahrache Nabil, Fadel Antoine J. Org. Chem. 2007, 72/5, 1780-1784 [PDF]
    • "2,2-Dimethyl-5-nitroso-1,3-dioxan-5-yl benzoate, 2,2-dimethyl-5-nitroso-1,3-dioxan-5-yl 4-chlorobenzoate and 5-nitroso-1,3-dioxan-5-yl 4-chlorobenzoate." Calvet Géraldine, Blanchard Nicolas, Kouklovsky Cyrille, Guillot Régis Acta Crystallographica Section C 2007, C63, o365-o368 [PDF]
    • " A Stereoselective Entry into Functionalized 1,2-Diamines by Zinc-Mediated Homologation of a-Aminoacids. " HOANG Cam Thuy, Alezra Valérie, Guillot Régis, Kouklovsky Cyrille Org. Lett. 2007, 9(13), 2521 - 2524 [PDF]
    • "Domino Metathesis of 3,6-Dihydro-1,2-oxazine: Access to Isoxazolo[2,3- a]pyridin-7-ones" Calvet Géraldine, Blanchard Nicolas, Kouklovsky Cyrille Org. Lett. 2007, 9, 1485-1488 [PDF]


    • "Synthesis of a-amino tetrahydropyranyl-, tetrahydrothiopyranyl-,  4- and 3-piperidinyl- phosphonic acids via phosphite addition to iminium ions." Rabasso Nicolas, Louaisil Nicolas, Fadel Antoine Tetrahedron 2006, 62, 7445-7454 [PDF]
    • "Stereoselective synthesis of (1R,2R)-1-amino-2-hydroxycyclobutanecarboxylic acid – serine derivative – , from racemic or optically active 2-benzyloxycyclobutanone." Hazelard Damien, Fadel Antoine, Girard Christian Tetrahedron: Asymmetry 2006, 17, 1457-1464 [PDF]
    • "First Synthesis of Heparan Sulfate Tetrasaccharides Containing both N-Acetylated and N-Unsubstituted Glucosamine - Search for Putative 10E4 Epitopes." Hamza Daniel, Lucas Ricardo, Feizi Ten, Chai Wengang, Bonnaffé David, Lubineau André ChemBioChem 2006, 7, 1856-1858 [PDF]
    • "Chemoenzymatic synthesis of the 3-sulfated Lewis a pentasaccharide." Malleron Annie, Hersant Yaël, Le Narvor Christine Carbohydrate Res. 2006, 341, 29-34
    • "Carbohydrate microarrays reveal sulphation as a modulator of siglec binding." Campanero-Rhodes Ma, Childs Ra, Kiso M, Komba S, Le Narvor Christine, Warren J, Otto D, Crocker Pr, Feizi T Biochemical and Biophysical Research Communications 2006, 344 (4), 1141-1146
    • " Asymmetric Aza-Diels-Alder Reaction of Danishesky's Diene with Imines in Chiral Reaction Medium " Pégot B., Nguyen Van Buu O., Gori Didier, VO-THANH Giang Belstein J. Org. Chem. 2006, 2, 18-21