Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Synthèse Organique et Méthodologie - LSOM

Some of our activities

Photooxygenation

According to the IUPAC, the photooxygenation is the incorporation of molecular oxygen into a molecular entity. In this video you will see the photooxygenation of cyclopentadiene.
Can you guess the structure of the product?

Our research

Highly Regio- and Stereoselective Nickel-Catalyzed Addition of Dialkyl Phosphites to Ynamides: an Efficient Synthesis of β-Aminovinylphosphonates

Fadel Antoine, Legrand Frédéric, Evano Gwilherm, Rabasso Nicolas Adv. Synth. Catal. 2011, 353, 263-267 [PDF]

A highly regio- and stereoselective, nickel(II)-catalyzed procedure for the hydrophosphonylation of ynamides has been developed. This protocol provides a straightforward and efficient entry to a series of &beta-aminovinylphosphonates that can easily be prepared in good yields from a wide range of ynamides and dialkyl phosphites as well as useful insights into the reactivity of ynamides under nickel catalysis.

 

Keywords

Aminoacids, Asymmetric synthesis, Heterocycles, Aminophosphonates, Enzymatic reactions, Quaternary centers, Cyclopeptides, Piperidines, Pyrrolidines, Photochemistry, [2+2] Cyloadditions, Kulinkvich reaction, Cyclopropanols, Natural products, Titanacyclopropanes, Palladium catalyzed reactions, Organosilicons compounds, Sila-chirality, Sila-diastereoselectivity, Diels-Alder Reaction, Radicalar reactions.