Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de RMN en milieu orienté - LRMN

Jonathan Farjon

john

Chercheur CNRS
Université Paris-Sud.
I.C.M.M.O.- UMR 8182
RMN en Milieu Orienté
Bât. 410
91405 ORSAY CEDEX
Tél : 01.69.15.47.67
jonathan.farjon@u-psud.fr

 

Personal Data

Ï Higher education :

2000-03 : PhD in Chemistry, speciality NMR with very honourable
                mention (University of Paris Sud 11)

2002-03 : MSc of Organic Chemistry (University of Paris Sud 11)

2001-02 : BSc of Chemistry (University of Cergy - Pontoise)

ÏAcademic positions held :

2009-11 : CNRS Associate Scientist 2nd class  (University of Paris  Sud 11)

2008 : Researcher, Structural Biology Institute (CEA of Grenoble)

2003-5: Research Fellow, NMR based structural biology, Max  Planck Institute, (Göttingen in Germany)

ÏAwards and Honours

Varian price of the best poster: J. Farjon, J. Boisbouvier, JP. Simorre, A. Pardi and B. Brutscher, XIeme NMR day in Rhône-Alpes, Villeurbanne, 2008.

Laureate from the German Academic Exchange Service (DAAD) fellowship (2003 - 2004)

ÏScientific expertise :

  • Expert for a Professor Assistant recruitment at the Paris V university (2011)

 

 

ÏScientific production :

- Total of peer-reviewed articles : 8
- Book articles : 1
- Oral communications : 7
- Posters (author/co-author) : 8
- Invited conferences : 3

Scientific collaborations

 

National
C. HENRY
(PFIZER, Fresnes, France)
2000 – 2003

Dr. J. C. PLAQUEVENT
(IRCOF, Rouen university, France)
2000 – 2003

Dr. M. BLACKLEDGE
(IBS, CEA of Grenoble, France)
2003 – 2005

Dr. B. BRUTSCHER
(CEA Grenoble)
2008

Prof. F. BANSE  and Dr K. SENECHAL - DAVID         
(Paris 11 university)       
2010-

Dr. J. HANNEDOUCHE
(Paris 11 university)       
2010-

International

Prof. C. GRIESINGER
 (Max Planck Institute of Göttingen, Germany)                     
2003 – 2005

Dr. W. BERMEL           
(Bruker Biospin, Rheinstetten, Germany)
2003 – 2005

Dr. H. KOGLER  
(SANOFI - AVENTIS, Frankfurt am Main, Germany)
2003 – 2005

 

Research Themes

ÏDevelopment of NMR methodologies

  • Simplification of spectra in oriented media: implementation of selective pulses [1] [3] and decoupling sequences [4]
  • Fast NMR experiments for following kinetics and for enhancing the sensitivity [2]

ÏOriented media synthesis [6]
Fields of application :
ÏQuantification of enantiomers
ÏStructural elucidation of synthetic and natural products [5]
ÏStructural determination of inorganic stable complexes and
reaction intermediates

Selected References

 

 

1/ “SERF-filtered experiments: new enantio-selective tools for deciphering complex spectra of racemic mixtures dissolved in chiral oriented media ”
    J. Farjon and D. Merlet, J. Magn Reson., 2011, 210, 24-30. http://www.sciencedirect.com/science/article/pii/S1090780711000565
2/ “ Longitudinal-relaxation-enhanced NMR experiments for the study of nucleic acids in solution”

     J. Farjon, J. Boisbouvier, P. Schanda, J-P. Simorre and B. Brutscher, J. Am. Chem. Soc., 2009, 131, 8571- 8577.
      http://pubs.acs.org/doi/abs/10.1021/ja901633y

3/ “ Selective NMR excitations in chiral analysis ”
     J. Farjon, L. Ziani, L. Beguin, D. Merlet and J. Courtieu, Annual Reports on NMR spect., 2007, 61, 283-293. http://www.sciencedirect.com/science/article/pii/S0066410307611053

4/ “  Resolution enhancement in spectra of natural products dissolved in weakly orienting media with the help of 1H homonuclear dipolar decoupling during acquisition: Application to 1H-13C dipolar couplings measurements ”

J. Farjon, W. Bermel and C. Griesinger, J. Magn. Reson.,2006, 180, 72-82.
http://www.sciencedirect.com/science/article/pii/S1090780706000139

5/ “ Effect of the solvent on the conformation of a depsipeptide: NMR derived solution structure of hormaomycin in DMSO by using residual dipolar couplings in a novel DMSO compatible alignment medium ”
U. Reinscheid, J. Farjon, M. Radzom, P. Haberz, A. Zeeck, M. Blackledge, C. Griesinger, ChemBioChem., 2006, 7, 287-296.
http://onlinelibrary.wiley.com/doi/10.1002/cbic.200500277/abstract

6/ A DMSO-Compatible Orienting Medium: Towards the Investigation of the Stereochemistry of Natural Products”

P. Haberz, J. Farjon and C. Griesinger, Angew. Chem., 2004, 44, 427-429.
      http://onlinelibrary.wiley.com/doi/10.1002/anie.200461267/abstract