Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie des Procédés et des Substances Naturelles- LCPSN

Jean-Pierre Férézou


Director of Research
LCPSN - ICMMO - Bât 410
Université Paris-Sud 11
15, rue Georges Clemenceau
91405 Orsay Cedex
FRANCE

Tel: +33 1 69 15 75 48
Fax: +33 1 69 15 46 79
Send an e-mail

 

Research Area (key words)


Synthesis of complex bioactive molecules, Hemisynthesis, Medicinal chemistry, Macrolactones.

Formation


Thèse de Doctorat d’Etat, Université de Paris Sud, 1981 « Sulfur and non sulfur piperazinediones from the phytopathogen fungus Phoma lingam Tode : chemical and biosynthetic studies »

Research career


01/2010             ICMMO, UMR CNRS 8182 (Dir. Jean-Pierre Mahy) Université Paris-Sud, Orsay, Laboratoire de Chimie des                      Procédés et des Substances Naturelles (LPSN).
2006-2009         Rehabilitation at CNRS, UMR 7652, at DCSO, Ecole Polytechnique, Palaiseau, Dir. Prof. Samir Zard.
1998-2006         Sabbatical leave from CNRS : research and consulting in Brazil
                           - 2003-2006 : PROTEC, Rio de Janeiro. Consulting in Innovation.
                           - 1998-2003 : Farmanguinhos (FIOCRUZ), Rio de Janeiro. Coordinator of Research in Organic Synthesis.
1993-1998       Laboratoire de Synthèse Organique (DCSO), Ecole Polytechnique, Palaiseau, Dir. Prof. Jean-Yves Lallemand.
1982-1993         Laboratoire de Chimie de l´Ecole Normale Supérieure, Paris, Supervisor Prof. Marc Julia.
                           - 1990 : Directeur de recherches II, CNRS.
1971-1982         Institut de Chimie des Substances Naturelles (ICSN), CNRS Gif sur Yvette
                           - 1974 : Intégration at CNRS as Stagiaire de Recherche.


Current position


Directeur de recherche CNRS at the Laboratoire de Synthèse des Substances Naturelles (dir. Professor Cyrille Kouklovsky), ICMMO, Université Paris-Sud, Orsay, France.


Some significative publications


"Ivermectin−derived leishmanicidal compounds"
A. Rouge dos Santos, C. A. B. Falcão , M. F. Muzitano, C. R. Kaiser, B. Rossi-Bergmann , J.-P. Férézou Bioorg. Med. Chem. 2009, 17, 496-502
"Formal convergent synthesis of Ivermectin aglycone: A synthetic approach to the C10−C25 subunit of Avermectins 2b"
V. Henryon; J.-P. Férézou Synthesis–Stuttgart 2009, 3477-3487
“Application of g-silyloxy allylditin to the efficient synthesis of the chromophore of Neocarzinostatin dihydroxycyclopentene-based dienediyne core”
D. Madec, J.-P. Férézou Eur. J. Org. Chem. 2006, 92-104
"Preparation of intact hexahydrobenzofuran subunits of Ivermectin by selective ozonolysis of the Δ3,4-intermediate secoester”
A. Rouge dos Santos, M. L. Garcia Ferreira, C. R. Kaiser, J.-P. FérézouEur. J. Org. Chem. 2005, 338-335
"Diastereocontrolled synthesis of highly functionalized spiroketals: application to the synthesis of a precursor of the C12-C25 fragment of bafilomycin A1
R. Lopez, J.-C. Poupon, E., J. Prunet, J.-P Férézou, L. Ricard Synthesis, 2005, 644-661
"Enantioselective synthesis of the C1-C11 fragment of Bafilomycin A1 using non-Wittig and desymmetrization strategies
J.-C. Poupon, E. Demont, J. Prunet, J.-P Férézou J. Org. Chem. 2003, 68, 4700-4707
“Hydroxy-directed diastereoselective installation of a methyl group on indalone models and spiroketal potential precursors for Bafilomycin A1 C12-C25 subunit”
J.-C. Poupon, R. Lopez, J. Prunet, J.-P. Férézou J. Org. Chem. 2002, 67, 2118-2124