Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Inorganique - LCI

Iron complexes, bioinspired catalysis

Frédéric Banse, Katell Sénéchal-David, Jean-Jacques Girerd
Nathalie Ségaud, Charlotte Buron


Coordination chemistry– preparation of reaction intermediates

 

 

Our projects deal with eco-friendship chemistry in order to develop alternative oxidations of small organic molecules. We are inspired by metalloenzymes that perform such difficult reaction in mild conditions, using iron and dioxygen. Starting from simple iron complexes, we aim at synthesizing some reaction intermediates that are models of enzymes key species. Monooxygenases like cytochromes P450, or dioxygenase like 2-oxoglutarate dependent enzymes catalyze oxygen atom insertion into inert substrates following reductive activation of dioxygen. This leads to reaction intermediates such as Fe-peroxo and high-valent iron-oxo. Our objectives are to prepare, detect and identify these types of species.

oxidation catalysis & mechanism

    

 

The second facet of our projects is the of use of our iron precursors in oxidation catalysis of small organic molecules (alkanes, alkenes, aromatic hydrocarbons…). Our objectives are to obtain efficient catalysts as well as determining the reaction mechanisms. In that goal, we are using isotop-labelled oxidants and substrates. In addition we are taking into account the intermediates obtained by reaction between the iron precursors and the oxidants

 

Recent thesis :

 

 

 

 

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