Institut de Chimie Moléculaire et des Matériaux d'Orsay

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Subject 2 (J.-P. Mahy)
Design and synthesis of new metal complexes
and study of their interactions with biomolecules

R. Ricoux, F. Avenier, W. Ghattas, J.-P. Mahy

 

 

2.11. Model complexes of b-lactamases
W. Ghattas

Current zinc and cobalt metal complexes perform poorly in mimicking the activity of β-lactamases. We identified the best performing complexes and are trying to improve their activity. This is performed by modifying their structure & coordinating atoms by biomiming the active sites of natural β-lactamases.