Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

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Thème 2 (J.-P. Mahy)
Conception et synthèse de nouveaux complexes métalliques
et étude de leurs interactions avec les biomolécules

R. Ricoux, F. Avenier, W. Ghattas, J.-P. Mahy


2.10. Métalloenzymes artificielles pour la théranostique
W. Ghattas

Agents targeting diseased tissue and combining diagnostic tools with therapeutics to combat different aspects of a disease are of major societal interest. We aim at the development and the assessment of hybrid molecules comprising a drug ligand of a membrane receptor bound to a metal-based catalyst.

These hybrid molecules will be designed to target drug 1 receptor in the affected tissue, wherein they will form artificial metalloenzymes that would be able to convert either a pro-drug 2 into an active drug or an imaging probe from the “off” state to the “on” state,respectively, at their target.