Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

The team's research is at the chemistry-biology interface and combine the areas of bioorganic chemistry and bioinorganic chemistry, first, to the fundamental study of biological processes at the molecular level, of secondly, the development of molecules or devices to meet the current major societal challenges relating to fields of health, energy and the environment, such as:

  • understanding the mechanisms of action of biomolecules (enzymes, metalloenzymes ...) and their interactions with natural or synthetic entities (substrates, inhibitors, metal complexes, electrochemical bioreceptors ...),
  • identifying original therapeutic targets for developing new types of drugs, including eco-design of molecules with therapeutic interest and the synthesis of prodrugs of the active ingredients in controlled release in space and time,
  • the development of artificial enzymes (artzymes) or bio-inspired catalysts for oxidation catalysis, enzymatic multicatalysis in cascade, oxidation of water, or enzymatic catalysis of new reactions,
  • the development of electrochemical biosensors and microfluidic devices for ultra sensitive and specific detection of biological biomarkers in body fluids or contaminants in environmental matrices.

    These scientific objectives are developed within three main thematics.

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