Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

Rémy Ricoux

Rémy Ricoux

Research Senior Scientist CNRS
Cristal du CNRS 2003


UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex (France)

Tel: +33 1 69 15 47 23
Fax: +33 1 69 15 72 81

send an email

Reasearch interests : Subject 2 

-Catalytic antibodies with heminic cofactors.
-Artificial analogues of hemoproteins (microperoxidase 8...).


Publications (2001-2017):

Reactions of persulfides with the heme cofactor of oxidized myoglobin and microperoxidase 11: reduction or coordination.
Erwan GALARDON, Florian HUGUET, Christian HERRERO, Rémy RICOUX, Isabelle ARTAUD and Dominique PADOVANIA
Dalton Trans. 2017, 46, 7939-7946.

αRep A3: A versatile artificial scaffold for metalloenzyme design.

Thibault DI MEO, Wadih GHATTAS, Christian HERRERO, Christophe VELOURS, Philippe MINARD, Jean-Pierre MAHY, Rémy RICOUX, and Agathe URVOAS
Chem. Eur. J.
2017, 23, 10156-10166.

Metal−Organic frameworks: a novel host platform for enzymatic catalysis and detection.
Effrosyni GKANIATSOU, Clémence SICARD, Rémy RICOUX, Jean-Pierre MAHY, Nathalie STEUNOU and Christian SERRE
Mater. Horiz. 2017, 4, 55-63.

Photoassisted Oxidation of Sulfides Catalyzed by Artificial Metalloenzymes Using Water as an Oxygen Source.

Christian HERRERO, Nhung NGUYEN-THI, Fabien HAMMERER, Frédéric BANSE, Donald GAGNE, Nicolas DOUCET, Jean-Pierre MAHY and Rémy RICOUX
Catalysts 2016, 6, 202.

Design, Synthesis and Reactivity of a New Kind of Eco-Compatible Hybrid Biocatalyst: Artificial Hemoproteins.
Jean-Pierre MAHY and Rémy RICOUX
in « Handbook of Porphyrin Science », 2016, volume 38: Towards Green Chemistry, World Scientific, ISBN: 978-981-3149-58-8, pp. 101-191, Karl M. KADISH, Kevin M. SMITH, Roger GUILARD (Eds.).
http://www.worldscientific.com/worldscibooks/10.1142/10055-vol38


Artificial metalloenzymes with the Neocarzinostatin-scaffold: toward a biocatalyst for the Diels–Alder cyclization reaction.
Wadih GHATTAS, Lur COTCHICO-ALONSO, Jean-Didier MARECHAL, Agathe URVOAS, Maëva ROUSSEAU, Jean-Pierre MAHY, Rémy RICOUX
ChemBioChem 2016, 17, 433-440
.

Oxidation catalysis via visible-light water activation of a [Ru(bpy)3]2+ chromophore BSA-metallocorrole couple.
Christian HERRERO, Annamaria QUARANTA, Rémy RICOUX, Alexandre TREHOUX, Atif MAHAMMED, Zeev GROSS, Frédéric BANSE and Jean-Pierre MAHY
Dalton Trans.
2015, 45, 706-710.

Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes.
Yoann ROUX, Rémy RICOUX, Frédéric AVENIER, Jean-Pierre MAHY
Nat. Commun. 2015, 6, 8509.

An Artificial Enzyme Made by Covalent Grafting of an FeII Complex into β-Lactoglobulin: Molecular Chemistry, Oxidation Catalysis, and Reaction-Intermediate Monitoring in a Protein.

Charlotte BURON, Katell SENECHAL-DAVID, Rémy RICOUX, Jean-Pierre LE CAËR, Vincent GUERINEAU, Philippe MEJANELLE, Régis GUILLOT, Christian HERRERO, Jean-Pierre MAHY and Frédéric BANSE
Chem. Eur. J. 2015, 21, 12188-12193.

From “hemoabzymes” to “hemozymes”: towards new biocatalysts for selective oxidations.
Jean-Pierre MAHY, Jean-Didier MARECHAL, Rémy RICOUX
Chem. Commun. 2015, 51, 2476-2494.

Various strategies for obtaining oxidative artificial hemoproteins with a catalytic oxidative activity: from "Hemoabzymes" to "Hemozymes"?
Jean-Pierre MAHY, Jean-Didier MARECHAL, and Rémy RICOUX
J. Porphyrins Phthalocyanines 2014, 18, 1063-1092.  

Neocarzinostatin-based hybrid biocatalysts with a RNase like activity.

Agathe URVOAS, Wadih GHATTAS, Jean-Didier MARECHAL, Frédéric AVENIER, Felix BELLANDE, Wei MAO, Rémy RICOUX, Jean-Pierre MAHY
Bioorg. Med. Chem. 2014, 22, 5678-5686.


Neocarzinostatin-based hybrid biocatalysts for oxidation reaction.
Elodie SANSIAUME-DAGOUSSET, Agathe URVOAS, Kaouthar CHELLY, Wadih GHATTAS, Jean-Didier MARECHAL, Jean-Pierre MAHY, Rémy RICOUX
Dalton Trans. 2014, 43, 8344-8354.

A unique 1-amino-1-cyclopropane carboxylate cupric-cryptate hosting sodium.
Wadih GHATTAS, Rémy RICOUX, Hafsa KORRI-YOUSSOUFI, Régis GUILLOT, Eric RIVIERE, Jean-Pierre MAHY
Dalton Trans. 2014, 43, 7707-7711.


Reactivity and X-ray structure of a new water-soluble manganese-salen complex.
M. ALLARD, R. RICOUX, R. GUILLOT, J.-P. MAHY
Inorg. Chim. Acta 2012, 382, 59-64.

Incorporation of manganese complexes into xylanase: new artificial metalloenzymes for enantioselective epoxidation.
M. ALLARD, C. DUPONT, V. MUŃOZ ROBLES, N. DOUCET, A. LLEDÓS, J.-D. MARÉCHAL, A. URVOAS, J.-P. MAHY, R. RICOUX
ChemBioChem 2012, 13, 240-251.

A new kind of eco-compatible hybrid biocatalystsfor selective reactions: artificial metalloenzymes.
Q. RAFFY, R. RICOUX, J.-P. MAHY
in Catalysis : Principles, Types and Applications; M. Song, Ed.; Nova Science Publishers, Inc.: Hauppauge (USA) 2011, 10, 31-62.

Estimation of kinetic parameters for the catalytic oxidation of substituted phenols in liquid phase.
D.-G. COZMA, A. PUI, R. RICOUX, J.-P. MAHY
Rev. Chim. (Bucharest) 2011, 62, 82-88.

Synthesis characterization and catalytic activity of some new manganese(II) compounds with tetra-chloro R-bis(salicylaldehyde) ethylenediamine and R-bis(salicylaldehyde) phenylenediamine ligands (R = H, CH3, CH2-CH3).
A. PUI, N. CORNEI, R. RICOUX, and J.-P. MAHY
Rev. Chim. (Bucharest) 2010, 61, 575-579

Oxidation of organic molecules in homogeneous aqueous solution catalyzed by hybrid biocatalysts (based on the Trojan Horse strategy).
E. SANSIAUME, R. RICOUX, D. GORI, and J.-P. MAHY
Tetrahedron: Asym. 2010, 21, 1593-1600.


A new generation of artificial enzymes: catalytic antibodies or 'abzymes'.
R. RICOUX and J.-P. MAHY
in Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W., Eds; Elsevier: Oxford 2010, 5, 323-352.

Coordination chemistry studies and peroxidase activity of a new artificial metalloenzyme built by the “Trojan horse” strategy.

Q. RAFFY, R. RICOUX, E. SANSIAUME, S. PETHE, and J.-P. MAHY
J. Mol. Catal. A: Chem. 2010, 317, 19-26.

Selective oxidation of aromatic sulfide catalyzed by an artificial metalloenzyme: new activity of hemozymes.
R. RICOUX, M. ALLARD, R. DUBUC, C. DUPONT, J.-D. MARECHAL, and J.-P. MAHY
Org. Biomol. Chem. 2009, 7, 3208-3211.

Various strategies for obtaining artificial hemoproteins: from “hemoabzymes” to “hemozymes”.
J.-P. MAHY, Q. RAFFY, M. ALLARD, and R. RICOUX
Biochimie
2009, 91, 1321-1323.

Intramolecular hydrogen bonding as a determinant of the inhibitory potency of N-substituted imidazole derivatives towards mammalian hemoproteins.
L. PERRIN, F. ANDRÉ, C. ANINAT, R. RICOUX, J.-P. MAHY, N. SHANGGUAN, M. M. JOUILLÉ, and M. DELAFORGE
Metallomics
2009, 1, 148-156.

Elaboration of a new hydrogen peroxide biosensor using microperoxidase 8 (MP8) immobilized on a polypyrrole coated electrode.
H. KORRI-YOUSSOUFI, N. DESBENOIT, R. RICOUX, J.-P. MAHY and S. LECOMTE
Mater. Sci. Eng. C 2008, 28, 855-860.

Hemozymes peroxidase activity of artificial hemoproteins constructed from the Streptomyces lividans Xylanase A and Iron(III)-carboxy-substituted porphyrins.
R. RICOUX, R. DUBUC, C. DUPONT, J.-D. MARECHAL, A. MARTIN, M. SELLIER, and J.-P. MAHY
Bioconjugate Chem. 2008, 19, 899-910.


Synthesis of a new estradiol-iron metalloporphyrin conjugate used to build up a new hybrid biocatalyst for selective oxidations by the “Trojan horse” strategy.
Q. RAFFY, R. RICOUX, and J.-P. MAHY
Tetrahedron Lett. 2008, 49, 1865-1869..

New biocatalysts mimicking oxidative hemoproteins: hemoabzymes.  
R. RICOUX, Q. RAFFY, and J.-P. MAHY    
C. R. Chimie 2007, 10, 684-702.

Microperoxidase 8 as a powerful tool for biological applications.
R. RICOUX, H. KORRI-YOUSSOUFI, and J.-P. MAHY
J. Biol. Sci. 2005, 5, 44-49.

Spectroscopic investigation of isonitrile complexes of ferric and ferrous microperoxidase 8.
R. RICOUX, S. LECOMTE, C. POLICAR, J.-L. BOUCHER, and J.-P. MAHY
J. Inorg. Biochem. 2005, 99, 1165-1173.

Design and synthesis of a Mn(III)-porphyrin steroid conjugate used as a new cleavable affinity label: on the road to semi-synthetic catalytic antibodies.
E. GIRGENTI, R. RICOUX, and J.-P. MAHY
Tetrahedron 2004, 60, 10049-10058.

Microperoxidase 8 adsorbed on a roughened silver electrode as a monomeric high-spin penta-coordinated species: characterization by SERR spectroscopy and electrochemistry.
S. LECOMTE, R. RICOUX, J.-P. MAHY , and H. KORRI-YOUSSOUFI
J. Biol. Inorg. Chem. 2004, 9, 850-858.

New activities of a catalytic antibody with a peroxidase activity. Formation of Fe(III)-RNO complexes and stereoselective oxidation of sulfides.
R. RICOUX, E. LUKOWSKA, F. PEZZOTTI, and J.-P. MAHY
Eur. J. Biochem. 2004, 271, 1277-1283.

Microperoxydase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxides.
R. RICOUX, J.-L. BOUCHER, D. MANDON, Y.-M. FRAPART, Y. HENRY, D.MANSUY, and J.-P. MAHY
Eur. J. Biochem. 2003, 270, 1-9.

New biocatalysts mimicking oxidative hemoproteins: hemoabzymes.
R. RICOUX, E. GIRGENTI, and J.-P. MAHY
Recent Res. Devel. Biochem. 2003, 4, 1-22.


Hemoabzymes: towards new biocatalysts for selective oxidation.
R. RICOUX, H. SAURIAT-DORIZON, E. GIRGENTI, D. BLANCHARD, and J.-P. MAHY
J. Immunol. Methods 2002, 269, 39-57.

Regioselective nitration of phenol induced by catalytic antibodies.
R. RICOUX, E. GIRGENTI, H. SAURIAT-DORIZON, D. BLANCHARD, and J.-P. MAHY
J. Protein Chem. 2002, 21, 471-475.

Anticorps catalytiques. Vrais outils ou leurres pour le chimistes ?
R. RICOUX, H. SAURIAT-DORIZON, E. GIRGENTI et J.-P. MAHY
L'Actualité Chimique 2002, août-septembre, 13-17.


Microperoxidase 8 (MP8) as a convenient model for hemoproteins : formation and characterization of new iron(II)-nitrosoalkane complexes of biological relevance.
R. RICOUX, J.-L. BOUCHER, D. MANSUY, and J.-P. MAHY
Adv. Exp. Med. Biol. 2001, 500, 149-152.


N-Hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8.
D. LEFEVRE-GROBOILLOT, S. DIJOLS, J.-L. BOUCHER, J.-P. MAHY, R. RICOUX, A. DESBOIS, J.-L. ZIMMERMANN, and D. MANSUY
Biochemistry 2001, 40, 9909-9917.

Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals.
R. RICOUX, J.-L. BOUCHER, D. MANSUY, and J.-P. MAHY
Eur. J. Biochem.
2001, 268, 3783-3788.



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