Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

Florence Ramiandrasoa

Florence Ramiandrasoa

Research Senior Scientist CNRS

UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex (France)

Tel : +33 1 69 15 47 20
Fax : +33 1 69 15 72 81

send an email

FT-IR supervisor

Research interests :
Subject 2

DNA molecular recognition by porphyrinic ligands : synthesis of new porphyrins-peptides intercalating into DNA and targeting specifically a HIV-1 sequence. Synthesis of DNA bis- and tris-intercalating derivatives.

Publications (2001-2017):


Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Elodie JAGU, Sébastien POMEL, Alba DIEZ-MARTINEZ, Florence RAMIANDRASOA , R. Luise KRAUTH-SIEGEL, Stéphanie PETHE, Casimir BLONSKI, Raphaël LABRUERE, Philippe M. LOISEAU
Bioorg. Med. Chem. 2017, 25, 84-90.


Design, synthesis and in vitro antikinetoplastid evaluation of N-acylated putrescine, spermidine and spermine derivatives.
Elodie JAGU, Rachid DJILLALI, Sébastien POMEL, Florence RAMIANDRASOA, Stéphanie PETHE, Raphaël LABRUERE, Philippe M. LOISEAU, Casimir BLONSKI
Bioorg. Med. Chem. Lett. 2015, 25, 207-209.

Synthesis and Biological Evaluation of Acridine Derivatives as Antimalarial Agents.
Xiao-Min YU, Florence RAMIANDRASOA, Lucie GUETZOYAN, Bruno PRADINES, Edgar QUINTINO, Danièle GADELLE, Patrick FORTERRE, Thierry CRESTEIL, Jean-Pierre MAHY, and Stéphanie PETHE
ChemMedChem 2012, 7, 587-605.


Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin.
L. GUETZOYAN, X.-M. YU, F. RAMIANDRASOA, S. PETHE, C. ROGIER, B. PRADINES, T. CRESTEIL, M. PERREE-FAUVET, and J.-P. MAHY
Bioorg. Med. Chem. 2009, 17, 8032-8039.

In vitro efficiency of new acridyl derivatives against Plasmodium falciparum.
L. GUETZOYAN, F. RAMIANDRASOA, H. DORIZON, C. DESPREZ, A. BRIDOUX, C. ROGIER, B . PRADINES, and M. PERREE-FAUVET
Bioorg. Med. Chem.
2007, 15, 3278-3289.

In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum.
B. PRADINES, A. TALL, F. RAMIANDRASOA, A. SPIEGEL, C. SOKHNA, T. FUSAI, J. MOSNIER, W. DARIES, J. F. TRAPE, G. KUNESCH, D. PARZY, and C. ROGIER
J. Antimicrob. Chemother. 2006, 57, 1093-1099.

Generation of free radicals and enhancement of hemin-induced membrane damage by a catechol iron chelator in Plasmodium falciparum.
B. PRADINES, F. RAMIANDRASOA, T. FUSAI, A. HAMMADI, M. HENRY, S. BRIOLANT, E. ORLANDI-PRADINES, J. MOSNIER, E. BARET, G. KUNESCH, J. LE BRAS, and C. ROGIER
J. Biol. Sci. 2005, 5, 463-471.

Iron chelators as antimalarial agents: in vitro activity of dicatecholate against Plasmodium falciparum.
B. PRADINES, J.-M. ROLAIN, F. RAMIANDRASOA, T. FUSAI, J. MOSNIER, C. ROGIER, W. DARIES, E. BARET, G. KUNESCH, J. LE BRAS, and D. PARZY
J. Antimicrob. Chemother. 2002, 50, 177-187.

In vitro potentiation of antibiotic activities by a catecholate iron chelator against chloroquine-resistant plasmodium falciparum.
B. PRADINES, F. RAMIANDRASOA, J.-M. ROLAIN, C. ROGIER, J. MOSNIER, W. DARIES, T. FUSAI, G. KUNESCH, J. LE BRAS, and D. PARZY
Antimicrob. Agents Chemother. 2002, 46, 225-228.

Kinetics and thermodynamics of complex formation between Fe(III) and two synthetic chelators of the dicatecholspermidine family.
J. M. E. CHAHINE, A. M. BAUER, K. BARALDO, C. LION, F. RAMIANDRASOA, and G. KUNESH
Eur. J. Inorg. Chem. 2001, 2287-2296.

New Mn(II) complexes with N/O coordination sphere from tripodal N-centered ligands. Characterization from solid state to solution and reaction with superoxide in non-aqueous media.
C. POLICAR, S. DUROT, F. LAMBERT, M. CESARIO, F. RAMIANDRASOA, and I. MORGENSTERN-BADARAU
Eur. J. Inorg. Chem.
2001, 1807-1818.


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