Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

Jean-Pierre Mahy

Jean Pierre Mahy

Professor

UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420

91405 Orsay Cedex (France)

Tel : +33 1 69 15 74 21
Fax : +33 1 69 15 72 81

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Director of Master Recherche M2 "Chemistry and Physical Chemistry: from Molecules to Biosystems" (Bioorganic and Bioinorganic Chemistry)

Research interests: Subject 2

-Elucidation of the mechanism of interaction of various chemical compounds with hemoproteins like hemoglobine, P450 cytochromes, prostaglandine H synthase, NO- synthase, "in vitro", thereafter "in vivo" ; determination of the mechanism of action and active site topology of hemoproteins still rather unknown like prostaglandine H synthetase.

-Elaboration of simple systems based on metalloporphyrins for the achievement of selective and efficient different types of reactions, like the oxidation of alkanes and alkenes: a) iron tetraarylporphyrins or microperoxydase 8 associated to oxene donors in homogeneous organic medium (iodosobenzene, hydrogen peroxide, alkyl hydroperoxydes), b) artificial hemoproteines, built either from anti-porphyrin antibodies, or by covalent link of metalloporphyrins on anti-substrat antibodies, c) iron tetraarylporphyrins or microperoxydase 8 bound on electrode: bioelectrocatalysis of selective oxidation reactions.

-Study of superoxide dismutases and of iron and manganese non-heminic model complexes.


Teaching:

PCEM1
Organic chemistry
General chemistry

Master de Chimie M1
Biophysics
Chemistry of metalloproteins
Chemistry of nucleotides

Magistère de Physico-Chimie Moléculaire
Biophysics
Master Recherche M2 de Chimie Organique
Biopolymers, polymers and bioorganic chemistry
Master recherche M2 Ingeniérie et Chimie des Biomolécules (ICBM)
Metals in biology and biocatalysis
Reaction mechanisms in organic, bioorganic, and bioinorganic chemistry


Publications (2001-2017) :

Elucidating the light-induced charge accumulation in an artificial analogue of methane monooxygenase enzymes using time-resolved x-ray absorption spectroscopy.
Dooshaye. MOONSHIRAM, Antonio PICON, Alvaro VASQUEZ-MAYAGOITIA, Xiaoyi ZHANG, Ming-Feng TU, Pablo GARRIDO-BARROS, Jean-Pierre MAHY, Frédéric AVENIER and Ally AUKAULOO
Chem. Commun. 2017, 53, 2725-2728.

Metal−Organic frameworks: a novel host platform for enzymatic catalysis and detection.
Effrosyni GKANIATSOU, Clémence SICARD, Rémy RICOUX, Jean-Pierre MAHY, Nathalie STEUNOU and Christian SERRE
Mater. Horiz. 2017, 4, 55-63.

Photoassisted Oxidation of Sulfides Catalyzed by Artificial Metalloenzymes Using Water as an Oxygen Source.

Christian HERRERO, Nhung NGUYEN-THI, Fabien HAMMERER, Frédéric BANSE, Donald GAGNE, Nicolas DOUCET, Jean-Pierre MAHY and Rémy RICOUX
Catalysts 2016, 6, 202

Reduction of a Tris(picolyl)amine Copper(II) Complex by a Polymeric Flavo-Reductase Model in Water.
Khaleb CHEAIB, Yoann ROUX, Christian HERRERO, Alexandre TREHOUX, Frédéric AVENIER and Jean-Pierre MAHY
Dalton Trans. 2016, 45, 18098-18101
.

Design, Synthesis and Reactivity of a New Kind of Eco-Compatible Hybrid Biocatalyst: Artificial Hemoproteins.
Jean-Pierre MAHY and Rémy RICOUX
in « Handbook of Porphyrin Science », 2016, volume 38: Towards Green Chemistry, World Scientific, ISBN: 978-981-3149-58-8, pp. 101-191, Karl M. KADISH, Kevin M. SMITH, Roger GUILARD (Eds.). http://www.worldscientific.com/worldscibooks/10.1142/10055-vol38

A growing family of O2 activating dinuclear iron enzymes with key catalytic diiron(III)-peroxo intermediates: biological systems and chemical models.
Alexandre TREHOUX, Jean-Pierre MAHY, Frédéric AVENIER
Coord. Chem. Rev. 2016, 322, 142-158.


Artificial metalloenzymes with the Neocarzinostatin-scaffold: toward a biocatalyst for the Diels–Alder cyclization reaction.
Wadih GHATTAS, Lur COTCHICO-ALONSO, Jean-Didier MARECHAL, Agathe URVOAS, Maëva ROUSSEAU, Jean-Pierre MAHY, Rémy RICOUX
ChemBioChem 2016, 17, 433-440
.

Oxidation catalysis via visible-light water activation of a [Ru(bpy)3]2+ chromophore BSA-metallocorrole couple.
Christian HERRERO, Annamaria QUARANTA, Rémy RICOUX, Alexandre TREHOUX, Atif MAHAMMED, Zeev GROSS, Frédéric BANSE and Jean-Pierre MAHY
Dalton Trans.
2015, 45, 706-710.

Bio-inspired electron-delivering system for reductive activation of dioxygen at metal centres towards artificial flavoenzymes.
Yoann ROUX, Rémy RICOUX, Frédéric AVENIER, Jean-Pierre MAHY
Nat. Commun. 2015, 6, 8509.

An Artificial Enzyme Made by Covalent Grafting of an FeII Complex into β-Lactoglobulin: Molecular Chemistry, Oxidation Catalysis, and Reaction-Intermediate Monitoring in a Protein.
Charlotte BURON, Katell SENECHAL-DAVID, Rémy RICOUX, Jean-Pierre LE CAËR, Vincent GUERINEAU, Philippe MEJANELLE, Régis GUILLOT, Christian HERRERO, Jean-Pierre MAHY and Frédéric BANSE
Chem. Eur. J. 2015, 21, 12188-12193.

Synthesis and characterization of [Fe(BPMEN)-ACC]SbF6: a structural and functional mimic of ACC-oxidase.
Yoann ROUX, Wadih GHATTAS, Frédéric AVENIER, Régis GUILLOT, A. Jalila SIMAAN and Jean-Pierre MAHY
Dalton Trans. 2015, 44, 5966-5968.


Catalytic Oxidation of Dibenzothiophene and thioanisole by a Diiron(III) Complex and Hydrogen Peroxide.
Alexandre TREHOUX, Yoann ROUX, Régis GUILLOT, Jean-Pierre MAHY, Frédéric AVENIER
J. Mol. Catal. A : Chem. 2015, 396, 40-46.

From “hemoabzymes” to “hemozymes”: towards new biocatalysts for selective oxidations.
Jean-Pierre MAHY, Jean-Didier MARECHAL, Rémy RICOUX
Chem. Commun. 2015, 51, 2476-2494.

Various strategies for obtaining oxidative artificial hemoproteins with a catalytic oxidative activity: from "Hemoabzymes" to "Hemozymes"?
Jean-Pierre MAHY, Jean-Didier MARECHAL, and Rémy RICOUX
J. Porphyrins Phthalocyanines 2014, 18, 1063-1092.

Neocarzinostatin-based hybrid biocatalysts with a RNase like activity.
Agathe URVOAS, Wadih GHATTAS, Jean-Didier MARECHAL, Frédéric AVENIER, Felix BELLANDE, Wei MAO, Rémy RICOUX, Jean-Pierre MAHY
Bioorg. Med. Chem. 2014, 22, 5678-5686.


Catalytic C–H amination: a reaction now accessible to engineered natural enzymes.
Jean-Pierre MAHY, Jennifer CIESIELSKI, Philippe DAUBAN
Angew. Chem. Int. Ed. 2014, 53, 6862-6864.


Neocarzinostatin-based hybrid biocatalysts for oxidation reaction.
Elodie SANSIAUME-DAGOUSSET, Agathe URVOAS, Kaouthar CHELLY, Wadih GHATTAS, Jean-Didier MARECHAL, Jean-Pierre MAHY, Rémy RICOUX
Dalton Trans. 2014, 43, 8344-8354.

A unique 1-amino-1-cyclopropane carboxylate cupric-cryptate hosting sodium.
Wadih GHATTAS, Rémy RICOUX, Hafsa KORRI-YOUSSOUFI, Régis GUILLOT, Eric RIVIERE, Jean-Pierre MAHY
Dalton Trans. 2014, 43, 7707-7711.

Photoassisted Generation of a Dinuclear Iron(III) Peroxo Species and Oxygen-Atom Transfer.
Frédéric AVENIER, Christian HERRERO, Winfried LEIBL, Alain DESBOIS, Régis GUILLOT, Jean-Pierre MAHY, Ally AUKAULOO
Angew. Chem. Int. Ed. 2013, 52, 3634–3637.

Crystal structure of two anti-porphyrin antibodies with peroxidase activity.
Victor MUNOZ ROBLES, Jean-Didier MARECHAL, Amel BAHLOUL, Marie-Agnès SARI, Jean-Pierre MAHY, Béatrice GOLINELLI-PIMPANEAU
Plos One 2012, 7, e51128.

Synthesis and Biological Evaluation of Acridine Derivatives as Antimalarial Agents.
Xiao-Min YU, Florence RAMIANDRASOA, Lucie GUETZOYAN, Bruno PRADINES, Edgar QUINTINO, Danièle GADELLE, Patrick FORTERRE, Thierry CRESTEIL, Jean-Pierre MAHY, and Stéphanie PETHE
ChemMedChem 2012, 7, 587-605.

Reactivity and X-ray structure of a new water-soluble manganese-salen complex.
M. ALLARD, R. RICOUX, R. GUILLOT, J.-P. MAHY
Inorg. Chim. Acta 2012, 382, 59-64.

Incorporation of manganese complexes into xylanase: new artificial metalloenzymes for enantioselective epoxidation.
M. ALLARD, C. DUPONT, V. MUŃOZ ROBLES, N. DOUCET, A. LLEDÓS, J.-D. MARÉCHAL, A. URVOAS, J.-P. MAHY, R. RICOUX
ChemBioChem 2012, 13, 240-251.

A new kind of eco-compatible hybrid biocatalystsfor selective reactions: artificial metalloenzymes.
Q. RAFFY, R. RICOUX, J.-P. MAHY
in Catalysis : Principles, Types and Applications; M. Song, Ed.; Nova Science Publishers, Inc.: Hauppauge (USA) 2011, 10, 31-62.

Estimation of kinetic parameters for the catalytic oxidation of substituted phenols in liquid phase.
D.-G. COZMA, A. PUI, R. RICOUX, J.-P. MAHY
Rev. Chim. (Bucharest) 2011, 62, 82-88.

Characterization of structure and activity of garlic peroxidase (POX1B).
S. EL ICHI, A. MIODEK, H. SAURIAT-DORIZON, J.-P. MAHY, C. HENRY, M. N. MARZOUKI, and H. KORRI-YOUSSOUFI
J. Biol. Inorg. Chem., 2011, 16, 157-172.

Effect of essential oil of Chromoleana odorata (Asteraceae) from Ivory Coast, on cyclooxygenase function of prostagladin-H synthase activity.
G. BEDI, Z. F. TONZIBO, K. R. OUSSOU, C. CHOPPARD, J.-P. MAHY and T. Y. N’GUESSAN
Afr. J. Pharm. Pharmacol. 2010, 4, 535-538.

Synthesis characterization and catalytic activity of some new manganese(II) compounds with tetra-chloro R-bis(salicylaldehyde) ethylenediamine and R-bis(salicylaldehyde) phenylenediamine ligands (R = H, CH3, CH2-CH3).
A. PUI, N. CORNEI, R. RICOUX, and J.-P. MAHY
Rev. Chim. (Bucharest) 2010, 61, 575-579.

Oxidation of organic molecules in homogeneous aqueous solution catalyzed by hybrid biocatalysts (based on the Trojan Horse strategy).
E. SANSIAUME, R. RICOUX, D. GORI, and J.-P. MAHY
Tetrahedron: Asym. 2010, 21, 1593-1600.

A new generation of artificial enzymes: catalytic antibodies or 'abzymes'.
R. RICOUX and J.-P. MAHY
in Comprehensive Natural Products II Chemistry and Biology; Mander, L., Lui, H.-W., Eds; Elsevier: Oxford 2010, 5, 323-352.

Coordination chemistry studies and peroxidase activity of a new artificial metalloenzyme built by the “Trojan horse” strategy.
Q. RAFFY, R. RICOUX, E. SANSIAUME, S. PETHE, and J.-P. MAHY
J. Mol. Catal. A: Chem. 2010, 317, 19-26.


Antimalarial acridines: Synthesis, in vitro activity against P. falciparum and interaction with hematin.
L. GUETZOYAN, X.-M. YU, F. RAMIANDRASOA, S. PETHE, C. ROGIER, B. PRADINES, T. CRESTEIL, M. PERREE-FAUVET, and J.-P. MAHY
Bioorg. Med. Chem. 2009, 17, 8032-8039.

Selective oxidation of aromatic sulfide catalyzed by an artificial metalloenzyme: new activity of hemozymes.
R. RICOUX, M. ALLARD, R. DUBUC, C. DUPONT, J.-D. MARECHAL, and J.-P. MAHY
Org. Biomol. Chem. 2009, 7, 3208-3211.

Various strategies for obtaining artificial hemoproteins: from “hemoabzymes” to “hemozymes”.
J.-P. MAHY, Q. RAFFY, M. ALLARD, and R. RICOUX
Biochimie
2009, 91, 1321-1323.

Intramolecular hydrogen bonding as a determinant of the inhibitory potency of N-substituted imidazole derivatives towards mammalian hemoproteins.
L. PERRIN, F. ANDRÉ, C. ANINAT, R. RICOUX, J.-P. MAHY, N. SHANGGUAN, M. M. JOUILLÉ, and M. DELAFORGE
Metallomics
2009, 1, 148-156.

Electrochemical detection of DNA sequences based on metalloporphyrins-polypyrrole towards a multi-detection analysis.
F. CANONNE, M. PERRÉE-FAUVET, J.-P. MAHY, and H. KORRI-YOUSSOUFI
Sensor Lett. 2008, 6, 570-576.


A new method of immobilization of proteins on activated ester terminated alkanethiol monolayers towards the label free impedancemetric detection.
C. TLILI, N. JAFFREZIC-RENAULT, C. MARTELET, J.-P. MAHY, S. LECOMTE, M. M. CHEHIMI, and H. KORRI-YOUSSOUFI
Mater. Sci. Eng. C
. 2008, 28, 861-868.

Elaboration of a new hydrogen peroxide biosensor using microperoxidase 8 (MP8) immobilized on a polypyrrole coated electrode.
H. KORRI-YOUSSOUFI, N. DESBENOIT, R. RICOUX, J.-P. MAHY, and S. LECOMTE
Mater. Sci. Eng. C 2008, 28, 855-860.

Hemozymes peroxidase activity of artificial hemoproteins constructed from the Streptomyces lividans Xylanase A and Iron(III)-carboxy-substituted porphyrins.
R. RICOUX, R. DUBUC, C. DUPONT, J.-D. MARECHAL, A. MARTIN, M. SELLIER, and J.-P. MAHY
Bioconjugate Chem. 2008, 19, 899-910.

Synthesis of a new estradiol-iron metalloporphyrin conjugate used to build up a new hybrid biocatalyst for selective oxidations by the “Trojan horse” strategy.
Q. RAFFY, R. RICOUX, and J.-P. MAHY
Tetrahedron Lett. 2008, 49, 1865-1869.

Flavocytochrome b2 : reactivity of its flavin with molecular oxygen.
A. K. OULD BOUBACAR, S. PETHE, J.-P. MAHY, and F. LEDERER
Biochemistry 2007, 46, 13080-13088.

Synthesis, characterization and catalytic activity of 3,5,3’,5’-tetra-halo-a-a’-dimethyl bis (salycilaldehyde) ethylenediamine cobalt(II) complexes.
A. PUI and J.-P. MAHY
Polyhedron 2007, 26, 3143-3152.

Electrochemical, spectroscopic characterization and catalytic activity of cobalt(II) complexes of tetra-chloro-R-Salen ([tClSalen = bis(3,5-di-chloro-alpha-R-salicylidene) ethylenediamine]) and tetra-chloro-R-Salophen ([tClSalophen = bis (3,5-di-chloro-alpha-R-salicylidene)- 1,2-phenylene-diamine]), R = H, CH3, CH2-CH3.
A. PUI, C. DOBROTA, and J.-P. MAHY      
J. Coord. Chem. 2007, 60, 581-595.

New biocatalysts mimicking oxidative hemoproteins: hemoabzymes.  
R. RICOUX, Q. RAFFY, and J.-P. MAHY    
C. R. Chimie 2007, 10, 684-702.

Electronic and steric effects in cobalt Schiff bases complexes. Synthesis, characterization and catalytic activity of some cobalt(II) tetra-halogens-dimethyl salen complexes.
A. PUI, C. POLICAR, and J.-P. MAHY
Inorg. Chim. Acta. 2007, 360, 2139-2144.

Novel electropolymerizable monomers which are soluble in aqueous solution and comprise a metalloporphyrin (Nouveaux monomères électropolymérisables, solubles en solution aqueuse comportant une métalloporphyrine).
F. CANONNE, H. KORRI-YOUSSOUFI, J.-P. MAHY, B. MANDRAND, M. PERREE-FAUVET
Brevet WO 2007/051947 (PCT/FR2006/051131), extension internationale de FR05/11187, déposée le 3 novembre 2006 par Biomérieux, le CNRS et l’Université Paris-Sud (dâte de publication internationale : 10 mai 2007).

Series of Mn complexes based on N-centered ligands and superoxide
- Reactivity in an anhydrous medium and SOD-like activity in an aqueous medium correlated to Mn(II)/Mn(III) redox potentials.
S. DUROT, C. POLICAR, F. CISNETTI, F. LAMBERT, J.-P. RENAULT, G. PELOSI, G. BLAIN, H. KORRI-YOUSSOUFI, and J.-P. MAHY
Eur. J. Inorg. Chem. 2005, 3513-3523.

Microperoxidase 8 as a powerful tool for biological applications.
R. RICOUX, H. KORRI-YOUSSOUFI, and J.-P. MAHY
J. Biol. Sci. 2005, 5, 44-49.

Spectroscopic investigation of isonitrile complexes of ferric and ferrous microperoxidase 8.
R. RICOUX, S. LECOMTE, C. POLICAR, J.-L. BOUCHER, and J.-P. MAHY
J. Inorg. Biochem. 2005, 99, 1165-1173.

Microperoxidase 8 adsorbed on a roughened silver electrode as a monomeric high-spin penta-coordinated species: characterization by SERR spectroscopy and electrochemistry.
S. LECOMTE, R. RICOUX, J.-P. MAHY , and H. KORRI-YOUSSOUFI
J. Biol. Inorg. Chem. 2004, 9, 850-858.

Design and synthesis of a Mn(III)-porphyrin steroid conjugate used as a new cleavable affinity label: on the road to semi-synthetic catalytic antibodies.
E. GIRGENTI, R. RICOUX, and J.-P. MAHY
Tetrahedron 2004, 60, 10049-10058.

Etude des effets anti douleurs des huiles essentielles de Chromolaena Odorata et de Mikania Cordata, par action sur la lipoxygénase L-1 de soja.
G. BÉDI, Z. F. TONZIBO, C. CHOPARD, J.-P. MAHY, and T. Y. N'GUESSAN
Phys. Chem. News 2004, 15, 124-127.

New activities of a catalytic antibody with a peroxidase activity. Formation of Fe(III)-RNO complexes and stereoselective oxidation of sulfides.
R. RICOUX, E. LUKOWSKA, F. PEZZOTTI, and J.-P. MAHY
Eur. J. Biochem. 2004, 271, 1277-1283.

Au confluent de la chimie et de la biologie-Rencontres enzymatiques.
J.-P. MAHY
Orsay Infos 2003 (n° 72) p. 7

Structural and magnetic properties of carboxylato-bridged manganese(II) complexes involving tetradentate ligands: discrete complex and 1D polymers. Dependence of J on the nature of the carboxylato bridge.
S. DUROT, C. POLICAR, G. PELOSI, F. BISCEGLIE, T. MALLAH, and J.-P. MAHY
Inorg. Chem.
2003, 42, 8072-8080.

New biocatalysts mimicking oxidative hemoproteins: hemoabzymes.
R. RICOUX, E. GIRGENTI, and J.-P. MAHY
Recent Res. Devel. Biochem. 2003, 4, 1-22.

Anti-inflammatory and analgesic activities: chemical constituents of essential oils of Ocimum gratissimum, Eucalyptus Citriodora and Cymbopogon Goganteus inhibited lipoxygenase L-1 and cycloxygenase of PGHS.
G. BEDI SAHOUO, Z. F. TONZIBO, B. BOTI, C. CHOPARD, J.-P. MAHY, and Y. T. N’GUESSAN
Bull. Chem. Soc. Ethiop. 2003, 17, 191-197.

Microperoxydase 8 catalysed nitrogen oxides formation from oxidation of N-hydroxyguanidines by hydrogen peroxides.
R. RICOUX, J.-L. BOUCHER, D. MANDON, Y.-M. FRAPART, Y. HENRY, D.MANSUY, and J.-P. MAHY
Eur. J. Biochem. 2003, 270, 1-9.

Hemoabzymes: towards new biocatalysts for selective oxidation.
R. RICOUX, H. SAURIAT-DORIZON, E. GIRGENTI, D. BLANCHARD, and J.-P. MAHY
J. Immunol. Methods 2002, 269, 39-57.

Regioselective nitration of phenol induced by catalytic antibodies.
R. RICOUX, E. GIRGENTI, H. SAURIAT-DORIZON, D. BLANCHARD, and J.-P. MAHY
J. Protein Chem. 2002, 21, 471-475.

Anticorps catalytiques. Vrais outils ou leurres pour le chimistes ?
R. RICOUX, H. SAURIAT-DORIZON, E. GIRGENTI et J.-P. MAHY
L'Actualité Chimique 2002, août-septembre, 13-17.

Coordination chemistry of iron(III)-porphyrin-antibody complexes.
S. de LAUZON, D. MANSUY, and J.-P. MAHY
Eur. J. Biochem. 2002, 269, 470-480.

Microperoxidase 8 (MP8) as a convenient model for hemoproteins : formation and characterization of new iron(II)-nitrosoalkane complexes of biological relevance.
R. RICOUX, J.-L. BOUCHER, D. MANSUY, and J.-P. MAHY
Adv. Exp. Med. Biol. 2001, 500, 149-152.

N-Hydroxyguanidines as new heme ligands: UV-visible, EPR, and resonance Raman studies of the interaction of various compounds bearing a C=NOH function with microperoxidase-8.
D. LEFEVRE-GROBOILLOT, S. DIJOLS, J.-L. BOUCHER, J.-P. MAHY, R. RICOUX, A. DESBOIS, J.-L. ZIMMERMANN, and D. MANSUY
Biochemistry 2001, 40, 9909-9917.

Microperoxidase 8 catalyzed nitration of phenol by nitrogen dioxide radicals.
R. RICOUX, J.-L. BOUCHER, D. MANSUY, and J.-P. MAHY
Eur. J. Biochem. 2001, 268, 3783-3788
.

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