Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

Wadih Ghattas

Wadih Ghattas


Permanent Researcher CNRS

UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex
France

Tel : +33 1 69 15 47 23
Fax : +33 1 69 15 72 81

send an email


Research interests :
Subject 2

Teaching :

IUT Chimie 2ème année
-TP IR / RMN


Publications (2006-2017):


αRep A3: A versatile artificial scaffold for metalloenzyme design.
Thibault DI MEO, Wadih GHATTAS, Christian HERRERO, Christophe VELOURS, Philippe MINARD, Jean-Pierre MAHY, Rémy RICOUX, and Agathe URVOAS
Chem. Eur. J.
2017, 23, 10156-10166.

2-Amino[1,2,4]triazolo[1,5-c]quinazolines and Derived Novel Heterocycles: Syntheses and Structure–Activity Relationships of Potent Adenosine Receptor Antagonists.
J. C. BURBIEL, W. GHATTAS, P. KUPPERS, M. KOSE, S. LACHER, A.-M. HERZNER, R. S. KOMBU, R. R. AKKINEPALLY, J. HOCKERMEYER, C. E. MULLER
ChemMedChem 2016, 11, 2272-2286.

Electrochemical DNA biosensors for bioterrorism prevention.
Hafsa KORRI-YOUSSOUFI, Anna MIODEK, Wadih GHATTAS
in “Biosensors for Security and Bioterrorism Applications”, 2016, Springer, ISBN : 978-3-319-28924-3, pp. 161-180, NIKOLELIS, Dimitrios P., NIKOLELI, Georgia-Paraskevi (Eds.). http://www.springer.com/gp/book/9783319289243

Artificial metalloenzymes with the Neocarzinostatin-scaffold: toward a biocatalyst for the Diels–Alder cyclization reaction.
Wadih GHATTAS, Lur COTCHICO-ALONSO, Jean-Didier MARECHAL, Agathe URVOAS, Maëva ROUSSEAU, Jean-Pierre MAHY, Rémy RICOUX
ChemBioChem 2016, 17, 433-440
.

Synthesis and characterization of [Fe(BPMEN)-ACC]SbF6: a structural and functional mimic of ACC-oxidase.
Yoann ROUX, Wadih GHATTAS, Frédéric AVENIER, Régis GUILLOT, A. Jalila SIMAAN and Jean-Pierre MAHY
Dalton Trans. 2015, 44, 5966-5968.


Synthesis of pincer-type N-heterocyclic carbene palladium complexes with a hemilabile ligand and their application in cross-coupling catalysis.
Vivienne LEIGH, Wadih GHATTAS, Helge MUELLER-BUNZ, Martin ALBRECHT
J. Organomet. Chem. 2014, 771, 33-39.

Neocarzinostatin-based hybrid biocatalysts with a RNase like activity.

Agathe URVOAS, Wadih GHATTAS, Jean-Didier MARECHAL, Frédéric AVENIER, Felix BELLANDE, Wei MAO, Rémy RICOUX, Jean-Pierre MAHY
Bioorg. Med. Chem. 2014, 22, 5678-5686.


Neocarzinostatin-based hybrid biocatalysts for oxidation reaction.
Elodie SANSIAUME-DAGOUSSET, Agathe URVOAS, Kaouthar CHELLY, Wadih GHATTAS, Jean-Didier MARECHAL, Jean-Pierre MAHY, Rémy RICOUX
Dalton Trans. 2014, 43, 8344-8354.

A unique 1-amino-1-cyclopropane carboxylate cupric-cryptate hosting sodium.
Wadih GHATTAS, Rémy RICOUX, Hafsa KORRI-YOUSSOUFI, Régis GUILLOT, Eric RIVIERE, Jean-Pierre MAHY
Dalton Trans. 2014, 43, 7707-7711.

Synthesis, Photo-, and Electrochemistry of Ruthenium Bis(bipyridine) Complexes Comprising a N-heterocyclic Carbene Ligand.
Leigh, V., Ghattas, W., Lalrempuia, R., Müller-Bunz, H., Pryce, M., Albrecht, M.
Inorg. Chem. 2013, 47, 5395-5402.

[1,2,4]Triazolo[1,5-c]quinazolin-2-amines – potent adenosine A1 and A2A receptor antagonists.
In: Abstracts of the Fourth Joint German-Italian Purine Club Meeting 2011
Ghattas, W., Burbiel, J.C., Hockemeyer, J. and Müller, C.E.
Purinergic Signalling 2012, 8, 107-175.

Tunable Single-site Ruthenium Complexes for Efficient Water Oxidation.
Bernet, L., Lalrempuia, R., Ghattas, W., Müller-Bunz, H., Vigara, L., Llobet, A. and Albrecht, M.
Chem. Comm. 2011, 47, 8058-8060.

Ru(bpy)3+ analogues containing a N-heterocyclic carbene ligand.
Ghattas, W., Müller-Bunz, H. and Albrecht, M.
Organometallics 2010, 29, 6782-6789.

Probing the Peptidylglycine α-Hydroxylating Monooxygenase active site with Novel 4-Phenyl-3-butenoic Acid Based inhibitors.
Langella, E., Pierre, S., Ghattas, W., Giorgi, M., Réglier, M., Saviano, M., Esposito, L. and Hardré, R.
ChemMedChem 2010, 5, 1568-1576.

Binding of the 2-hydroxypyridine-N-oxide on a dicopper(II) center: Insight into Tyrosinase inhibition mechanism by transition state analogues.
Peyroux, E., Ghattas, W., Hardré, R., Giorgi, M., Faure, B., Simaan, A. J., Belle, C. and Réglier, M.
Inorg. Chem. 2009, 48, 10874-10876.

Synthesis and characterization of a binuclear iron(III) complex bridged by 1-aminocyclopropane-1-carboxylic acid. Ethylene production in the presence of hydrogen peroxide.
Ghattas, W., Serhan, Z., El Bakkali-Taheri, N., Réglier, M., Kodera, M., Hitomi, Y. and Simaan, A. J.
Inorg. Chem. 2009, 48, 3910-3912.

Identification of a copper(I) intermediate in the conversion of ACC into ethylene in the presence of hydrogen peroxide by a Cu(II)-ACC complex.
Ghattas, W., Rockenbauer, A., Mekmouche, Y., Saint-Aman, E., Réglier, M., Hitomi, Y. and Simaan, A. J.
Inorg. Chem. 2008, 47, 4627-4638.

Characterization of Cu(II)-ACC complexes and conversion of the bound ACC into ethylene in the presence of hydrogen peroxide. Detection of a brown intermediate at low temperature.
Ghattas, W., Giorgi, M., Gaudin, C., Rockenbauer, A., Réglier, M. and Simaan, A. J.
Bioinorg. Chem. Appl. 2007, ID 43424, 1-9.

ACC-Oxidase like activity of a copper (II)–ACC complex in the presence of hydrogen peroxide. Detection of a reaction intermediate at low temperature.
Ghattas, W., Gaudin, C., Giorgi, M., Rockenbauer, A., Simaan, A. J. and Réglier, M.
Chem. Comm. 2006, 1027-1029.

Pathway for the stereocontrolled Z and E production of alpha,alpha-difluorine-substituted phenyl butenoates.
Ghattas, W., Hess, C., Iacazio, G., Hardré, R., Klinman, J. and Réglier, M.
J. Org. Chem. 2006, 71, 8618-8621.



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