Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

 

Casimir Blonski

Casimir Blonski


Directeur de Recherches CNRS

UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex

Tel: 33 (0) 1 69 15 47 25
Fax: 33 (0) 1 69 15 72 81

envoyer un mail

Domaines de recherche : Thème 1


Publications (2008-2016) :

Synthesis and in vitro antikinetoplastid activity of polyamine-hydroxybenzotriazole conjugates.
Elodie JAGU, Sébastien POMEL, Alba DIEZ-MARTINEZ, Florence RAMIANDRASOA , R. Luise KRAUTH-SIEGEL, Stéphanie PETHE, Casimir BLONSKI, Raphaël LABRUERE, Philippe M. LOISEAU
Bioorg. Med. Chem. 2016, accepted (http://dx.doi.org/10.1016/j.bmc.2016.10.013)


Methods of increasing the cytotoxicity of chemotherapeutic agents with multisubstrate inhibitors of histone, protein-Lys, polyamine acetylation, and polyamine metabolism.
Joseph PARELLO, Keya BANDYOPADHYAY, Jean-Louis BANERES, Casimir BLONSKI, Ruth Anne GJERSET, Aimée MARTIN
Patent n°: US 9,107,879 B1 - Date of patent: Aug. 18, 2015

Design, synthesis and in vitro antikinetoplastid evaluation of N-acylated putrescine, spermidine and spermine derivatives.
Elodie JAGU, Rachid DJILLALI, Sébastien POMEL, Florence RAMIANDRASOA, Stéphanie PETHE, Raphaël LABRUERE, Philippe M. LOISEAU, Casimir BLONSKI
Bioorg. Med. Chem. Lett. 2015, 25, 207-209.

New potent bisubstrate inhibitors of histone acetyltransferase p300: design, synthesis and biological evaluation.
F. H. A. KWIE, M. BRIET, D. SOUPAYA, P. HOFFMANN, M. MATURANO, F. RODRIGUEZ, C. BLONSKI, C. LHERBET, and C. BAUDOIN-DEHOUX
Chem. Biol. Drug Des. 2011, 77, 86-92.

Antitrypanosomal alkaloids from Polyalthia suaveolens (Annonaceae): their effects on three selected glycolytic enzymes of Trypanosoma brucei.
I. NGANTCHOU, B. NYASSE, C. DENIER, C. BLONSKI, V. HANNAERT, and B. SCHNEIDER
Bioorg. Med. Chem. Lett. 2010, 20, 3495-3498.

Bismuth(III) triflate: a safe and easily handled precursor for triflic acid: application to the esterification reaction.
F. H. A. KWIE, C. BAUDOIN-DEHOUX, C. BLONSKI, C. LHERBET
Synth. Comm. 2010, 40, 1082-1087.

Chemo-sensitization using cancer targeted spermidine-CoA based compound.
K. BANDYOPADHYAY, J.-L. BANERES, A. MARTIN, C. BLONSKI, J. PARELLO, R. A. GJERSET
Eur. J. Cancer Supplements 2010, 8, 164.

Spermidinyl-CoA-based HAT inhibitors block DNA repair and provide cancer-specific chemo- and radiosensitization.
K. BANDYOPADHYAY, J.-L. BANERES, A. MARTIN, C. BLONSKI, J. PARELLO, and R. A. GJERSET
Cell Cycle 2009, 8, 2779-2788.


Inhibitory effects of palmatine from Enantia chlorantha on Trypanosoma cruzi and Leishmania infantum.
E. T. NKWENGOUA, I. NGANTCHOU, B. NYASSE, C. DENIER, C. BLONSKI, and B. SCHNEIDER
Nat. Prod. Res. 2009, 23, 1144-1150.


Bismuth triflate-catalyzed oxa- and thia-Pictet-Spengler reactions: access to iso- and isothio-chroman compounds.
C. LHERBET, D. SOUPAYA, C. BAUDOIN-DEHOUX, C. ANDRE, C. BLONSKI, P. HOFFMANN
Tetrahedron Lett. 2008, 49, 5449-5451.

Synthesis and Evaluation of New Phosphonolipid Compounds for Gene Delivery.
A. DURAND DAL-MASO; J. DELLACASAGRANDE; F. LEGENDRE; G. TIRABY; C. BLONSKI, P. HOFFMANN
Eur. J. Med. Chem. 2008, 43, 1758-1766.

A Convenient Method for the Preparation of Heterodialkyl-H-Phosphonates from Diphenyl-H-Phosphonate.
A. DURAND DAL-MASO; F. LEGENDRE; C. BLONSKI, P. HOFFMANN
Synth. Commun. 2008, 38, 1688-1693.

Irreversible Inhibition of Aldolase by a Phosphorylated alpha-Dicarbonyl Compound.
N. CHABOT; V. VINATIER; T. GEFFLAUT; C. BAUDOIN; F. RODRIGUEZ; C. BLONSKI, P. HOFFMANN
J. Enzyme Inhib. Med. Chem. 2008, 23, 21-27.

Accueil LCBB