Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

 

Michel Therisod


Professeur émérite


UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex

Tel : 01 69 15 63 11
Fax : 01 69 15 72 81

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Domaines de recherche : Thème 1

Synthèse et évaluation d'inhibiteurs spécifiques des aldolases de classe II (à zinc); synthèse et évaluation des prodrogues lipophiles correspondantes. Nouvelles réactions de bioconversion catalysées par les peroxydases héminiques; applications en synthèse organique.


Enseignements :

Master de chimie M1
Mécanismes enzymatiques

Master Pro M2 Instrumentation et Méthodes d'Analyse Moléculaire
Stéréochimie

Licence de biologie L3
Synthèse peptidique


Publications (2001-2012) :

Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes : class II fructose-1,6-bis-phosphate alodolases, type I phosphomannose isomerase, and phosphoglucose isomerase.
S. DESVERGNES, S. COURTIOL-LEGOURD, R. DAHER, M. DABROWSKI, L. SALMON, M. THERISOD
Bioorg. Med. Chem. 2012, 20, 1511-1520.

Glycolytic and non-glycolytic functions of the fructose-1,6-bisphosphate aldolase of Mycobacterium tuberculosis, an essential enzyme produced by replicating and non-replicating bacilli

M. de la PAZ SANTANGELO, Petra M. GEST, Marcelo E. GUERIN, Mathieu COINCON, Ha PHAM, Gavin RYAN, Susan E. PUCKETT, John S. SPENCER, Mercedes GONZALES-JUARRERO, Racha DAHER, Anne J. LENAERTS, Dirk SCHNAPPINGER, Michel THERISOD, Sabine EHRT, Jurgen SYGUSCH and Mary JACKSON
J. Biol. Chem. 2011, 286, 40219-40231.

Mannitol bis-phosphate based inhibitors of fructose 1,6-bisphosphate aldolases.
C.-G. MABIALA-BASSILOUA, G. ARTHUS-CARTIER, V. HANNAERT, H. THERISOD, J. SYGUSCH, and M. THERISOD
ACS Med. Chem. Lett. 2011, 2, 804-808.

Rational design, synthesis and evaluation of new selective inhibitors of microbial class II (zinc dependent) fructose bis-phosphate aldolases.
R. DAHER, M. COINCON, M. FONVIELLE, P. M. GEST, M. E. GUERIN, M. JACKSON, J. SYGUSCH, and M. THERISOD
J. Med. Chem. 2010, 53, 7836-7842.

Highly Selective Inhibitors of Class II Microbial Fructose Bis-phosphate Aldolases.
R. DAHER and M. THERISOD
ACS Med. Chem. Lett. 2010, 1, 101-104.


Glucose oxidase-catalysed synthesis of aldonic acids.
F. PEZZOTTI, H. THERISOD, and M. THERISOD
in Practical Methods for Biocatalysis and Biotransformations, Eds. J. Whitall & P. W. Sutton, Wiley 2010, pp. 323-326.

Synthesis and biochemical evaluation of selective inhibitors of class II fructose bis-phosphate aldolases: toward new synthetic antibiotics.
M. FONVIELLE, M. COINÇON, R. DAHER, N. DESBENOIT, K. KOSIERADZKA, N. BARILONE, B. GICQUEL, J. SYGUSCH, M. JACKSON, and M. THERISOD
Chem. Eur. J. 2008, 14, 8521-8529.

Stereocontrol by a pair of epimeric sugar-derived ligands of the coordination sphere of copper(II) complexes.
F. CISNETTI, R. GUILLOT, M. THERISOD, M. DESMADRIL, and C. POLICAR
Inorg. Chem.
2008, 47, 2243-2245.


Separate synthesis and evaluation of glucitol bis-phosphate and mannitol bis-phosphate, as competitive inhibitors of fructose bis-phosphate aldolases.
C.-G. MABIALA-BASSILOUA, M. ZWOLINSKA, H. THERISOD, J. SYGUSCH, and M. THERISOD
Bioorg. Med. Chem. Lett. 2008, 18, 1735-1737.

Synthesis and X-ray crystal structures of two transition metal complexes based on functionalized 1,5-anhydro-2-deoxy-D-galacticol and methyl 2-deoxy-a-D-galactopyranoside.
F. CISNETTI, R. GUILLOT, N. IBRAHIM, F. LAMBERT, M. THERISOD, and C. POLICAR
Carbohydr. Res. 2008, 343, 530-535.

Diaqua[methyl 4-O-benzyl-2,3,6-tri-O-(2-picolyl)-b-D-mannopyranoside-cobalt(II) bis(perchlorate) mono-hydrate: partial coordination of a ligand derived from D-mannose.
F. CISNETTI, R. GUILLOT, M. THERISOD, and C. POLICAR
Acta Cryst.
2007, C63, m201-m203.

Enantioselective oxidation of thioanisole with an alcohol oxidase/peroxidase bienzymatic system.
F. PEZZOTTI and M. THERISOD
Tetrahedron: Asymmetry
2007, 18, 701-704.

New competitive inhibitors of cytosolic (NADH dependent) rabbit muscle glycerophosphate dehydrogenase.
M. FONVIELLE, H. THERISOD, M. HEMERY, and M. THERISOD
Bioorg. Med. Chem. Lett. 2007, 17, 410-413.

Enzymatic synthesis of aldonic acids.
F. PEZZOTTI and M. THERISOD
Carbohydr. Res. 2006, 341, 2290-2292.

Superoxide dismutase-like activity of cobalt(II) complexes based on a sugar platform.
F. BELLOT, R. HARDRÉ, G. PELOSI, M. THERISOD and C. POLICAR
Chem. Commun. 2005, 5414-5416.

Bienzymatic synthesis of chiral heteroayl-methyl-sulfoxides.
F. PEZZOTTI, K. OKRASA, and M. THERISOD
Tetrahedron: Asymmetry 2005, 16, 2681-2683.

New inhibitors of rabbit muscle triose-phosphate isomerase.
M. FONVIELLE, S. MARIANO, and M. THERISOD
Bioorg. Med. Chem. Lett. 2005, 15, 2906-2909.

Enzymatic synthesis of D-glucosaminic acid from D-glucosamine.
F. PEZZOTTI, H. THERISOD, and M. THERISOD
Carbohydr. Res. 2005, 340, 139-141.

Oxidation of chlorophenols catalyzed by Coprinus cinereus peroxidase with in situ production of hydrogen peroxide.
F. PEZZOTTI, K. OKRASA, and M. THERISOD
Biotechnol. Prog. 2004, 20, 1868-1871.

In vitro bi-enzymatic synthesis of benzaldehyde from phenylalanine: practical and mechanistic studies.
K. OKRASA, E. GUIBÉ-JAMPEL, J. PLENKIEWICZ, and M. THERISOD
J. Mol. Catal. B: Enzym. 2004, 31, 97-101.

New highly selective inhibitors of class II fructose-1,6-bisphosphate aldolases.
M. FONVIELLE, P. WEBER, K. DABKOWSKA, and M. THÉRISOD
Bioorg. Med. Chem. Lett. 2004, 14, 2923-2926.

Ionic liquids as a new reaction medium for oxidase-peroxidase-catalyzed sulfoxidation.
K. OKRASA, E. GUIBÉ-JAMPEL, and M. THÉRISOD
Tetrahedron: Asym. 2003, 14, 2487-2490.

New facile synthesis of phosphoglycolohydroxamic acid and other phosphoglycolic acid derivatives.
P. WEBER, M. FONVIELLE, AND M. THÉRISOD
Tetrahedron Lett. 2003, 44, 9047-9049.

Enantioselective synthesis of sulfoxides catalysed by an oxidase-peroxidase bienzymatic system.
K. OKRASA, A. FALCIMAIGNE, E. GUIBE-JAMPEL, and M. THÉRISOD
Tetrahedron: Asymmetry. 2002, 13, 519-52.

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