Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

 

Clotilde Policar


Maître de Conférences  (HDR)
UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex

Tel: 33 (0) 1 69 15 47 25
Fax: 33 (0) 1 69 15 72 81

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Domaines de recherche / Research interests :
Thème 2 / Subject 2

Synthèse et évaluation de complexes mimes de sites actifs de métalloprotéines : application à la synthèse complexes mimes des superoxyde-dismutases (SODs) à fer ou à manganèse / Synthesis and evaluation of complexes designed as mimics of metalloproteins active sites : mononuclear non-hemic iron and manganese complexes as synzymes of superoxide dismutase (SOD).

Enseignements / Teaching :

Magistère InterUniversitaire de Chimie (Paris VI, VII, XI, XIII et ENS)

Chimie bioorganique et bioinorganique (Cours) / Bioorganic and bioinorganic chemistry (Lectures)

Master Pro M2 Instrumentation et Méthodes d'Analyse Moléculaire

Spectroscopie de Résonance Paramagnétique Electronique (Cours) / Electron Paramagnetic Resonance spectroscopy (Lectures)

Master de Chimie M1

Histoire des sciences / History of sciences
Magnétisme et spectroscopies de RPE, UV-visible et Mössbauer / Magnetism and EPR, UV-visible and Mössbauer spectrocopies
Chimie inorganique / Inorganic chemistry
Chimie des métalloprotéines / Chemistry of metalloproteins

Préparation à l'agrégation de Sciences Physiques, option chimie (ENS Cachan)

Mises au point en chimie bioinorganique, cinétique enzymatique, spectroscopie de résonance paramagnétique électronique et magnétisme / EPR, magnetism, enzymatic kinetic, bioinorganic chemistry (Lectures)


Licence de Sciences Physiques

Magistère de Physico-Chimie Moléculaire
Histoire de la Chimie / History of Chemistry

Publications / publications (2001-2008) :

Synthesis, characterization, and dioxygen reactivity of copper(I) complexes with glycoligands.
Z. DAMAJ, F. CISNETTI, L. DUPONT, E. HENON, C. POLICAR, and E. GUILLON
Dalton Trans. 2008, 2235-2245.

Stereocontrol by a pair of epimeric sugar-derived ligands of the coordination sphere of copper(II) complexes.
F. CISNETTI, R. GUILLOT, M. THERISOD, M. DESMADRIL, and C. POLICAR
Inorg. Chem.
2008, 47, 2243-2245.


Synthesis and X-ray crystal structures of two transition metal complexes based on functionalized 1,5-anhydro-2-deoxy-D-galacticol and methyl 2-deoxy-a-D-galactopyranoside.
F. CISNETTI, R. GUILLOT, N. IBRAHIM, F. LAMBERT, M. THERISOD, and C. POLICAR
Carbohydr. Res. 2008, 343, 530-535.

Synthesis and cellular uptake of superparamagnetic dextran-nanoparticules with porphyrinic motifs grafted by esterification.
R. LUCAS, R. GRANET, V. SOL, C. LE MORVAN, C. POLICAR, E. RIVIERE, and P. KRAUSZ
e-Polymers 2007, 089, 1-8.

A new pentadentate ligand forms both a di- and a mononuclear Mn(II) complex: electrochemical, spectroscopic and superoxide dismutase activity studies.
F. CISNETTI , A.-S. LEFEVRE, R. GUILLOT, F. LAMBERT, G. BLAIN, E. ANXOLABEHERE-MALLART, and C. POLICAR
Eur. J. Inorg. Chem. 2007,4472-4480.

Glycoligands tuning the magnetic anisotropy of Ni(II) complexes.
G. CHARRON, F. BELLOT, F. CISNETTI, G. PELOSI, J.-N. REBILLY, E. RIVIÈRE, A.-L. BARRA, T. MALLAH, and C. POLICAR
Chem. Eur. J. 2007, 13, 2774-2782.

Reactivity of Mn(II) with superoxide. Evidence for a [Mn(III)OO]+ unit by low-temperature spectroscopies.
S. GRONI, G. BLAIN, R. GUILLOT, C. POLICAR, and E. ANXOLABEHERE-MALLART
Inorg. Chem. 2007, 46, 1951-1953.

Diaqua[methyl 4-O-benzyl-2,3,6-tri-O-(2-picolyl)-a-D-mannopyranoside]-cobalt(II) bis(perchlorate) mono-hydrate: partial coordination of a ligand derived from D-mannose.
F. CISNETTI, R. GUILLOT, M. THERISOD, and C. POLICAR
Acta Cryst. 2007, C63, m201-m203.

Glycoligands and Co(II) glycocomplexes. Investigation of the variation of the sugar-scaffold on the structure and chirality measured by circular dichroism.
F. CISNETTI, R. GUILLOT, M. DESMADRIL, G. PELOSI, and C. POLICAR
Dalton Trans. 2007, 1473-1476.

Electronic and steric effects in cobalt Schiff bases complexes. Synthesis, characterization and catalytic activity of some cobalt(II) tetra-halogens-dimethyl salen complexes.
A. PUI, C. POLICAR, and J.-P. MAHY
Inorg. Chim. Acta. 2007, 360, 2139-2144.

Characterization of purified green bell pepper hydroperoxide lyase expressed by Yarrowia lipolytica: radicals detection during catalysis.
M. SANTIAGO-GOMEZ, C. VERGELY, C. POLICAR, J.-M. NICAUD, J.-M. BELIN, L. ROCHETTE, and F. HUSSON
Enzyme Microbiol. Technol. 2007, 41, 13-18.

Synthesis and superoxide dismutase-like activity of new manganese(III) complexes based on tridentate N2O ligands derived from histamine.
F. CISNETTI, G. PELOSI and C. POLICAR
Inorg. Chim. Acta 2007, 360, 557-562.

Penser en trois dimensions : un saut épistémologique en chimie.
C. POLICAR
« Symétries », ouvrage collectif interdisciplinaire, chap. 4, pp. 57-91, Ed. Hermès, Paris, 2005.

Synthesis and X-ray structure of the Mn(II)Cl2 and Mn(III)F2 complexes of N,N'-dimethyl-2,11-diaza[3,3](2,6)pyridinophane. High-field electron paramagnetic resonance and density funtional theory studies of the Mn(III) complex. Evidence for a low-lying spin triplet state.
B. ALBELA, R. CARINA, C. POLICAR, S. POUSSEREAU, J. CANO, J. GUILHEM, L. TCHERTANOV, G. BLONDIN, M. DELROISSE, and J.-J. GIRERD
Inorg. Chem. 2005, 44, 6959-6966.


Superoxide dismutase-like activity of cobalt(II) complexes based on a sugar platform.
F. BELLOT, R. HARDRÉ, G. PELOSI, M. THERISOD and C. POLICAR
Chem. Commun. 2005, 5414-5416.

Mn(III) N2O2 complex as part of a Mn N-centered ligand series. Reactivity towards superoxyde in aqueous medium correlated to Mn(II)/Mn(III) redox potentials.
C. POLICAR, S. DUROT, F. CISNETTI, F. LAMBERT, J.-P. RENAULT, and G. PELOSI
Eur. J. Inorg. Chem. 2005, 3513-3523.

A pulse radiolysis study of catalytic superoxide radical dismutation by a manganese(II) complex with an N-tripodal ligand
S. DUROT, F. LAMBERT, J.-P. RENAULT, and C. POLICAR
Eur. J. Inorg. Chem. 2005, 2789-2793.

Spectroscopic investigation of isonitrile complexes of ferric and ferrous microperoxidase 8.
R. RICOUX, S. LECOMTE, C. POLICAR, J.-L. BOUCHER, and J.-P. MAHY
J. Inorg. Biochem. 2005, 99, 1165-1173.

Imidazole and imidazolate iron complexes: on the way for tuning 3D-structural characteristics and reactivity. Redox interconversions controled by protonation state.
F. LAMBERT, C. POLICAR, S. DUROT, M. CESARIO, L. YUWEI, H. KORRI-YOUSSOUFI, B. KEITA, and L. NADJO
Inorg. Chem. 2004, 43, 4178-4188.

Structural and magnetic properties of carboxylato-bridged manganese(II) complexes involving tetradentate ligands: discrete complex and 1D polymers. Dependence of J on the nature of the carboxylato bridge.
S. DUROT, C. POLICAR, G. PELOSI, F. BISCEGLIE, T. MALLAH, and J.-P. MAHY
Inorg. Chem. 2003, 42, 8072-8080.

Modeling copper(I) complexes: SIBFA molecular mechanics versus ab initio energetics and geometrical arrangements.
N. GRESH, C. POLICAR, and C. GIESSNER-PRETTRE
J. Phys. Chem. A 2002, 106, 5660-5670.

The origin of chemical and configurational stability of chiral non-racemic tert-butyl aziridinecarboxylate anions.
V. ALEZRA, M. BONIN, L. MICOUIN, C. POLICAR, and H. P. HUSSON
Eur. J. Org. Chem. 2001, 2589-2594.

New Mn(II) complexes with N/O coordination sphere from tripodal N-centered ligands. Characterization from solid state to solution and reaction with superoxide in non-aqueous media.
C. POLICAR, S. DUROT, F. LAMBERT, M. CESARIO, F. RAMIANDRASOA, and I. MORGENSTERN-BADARAU
Eur. J. Inorg. Chem. 2001, 1807-1818.

 
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