Institut de Chimie Moléculaire et des Matériaux d'Orsay

Laboratoire de Chimie Bioorganique et Bioinorganique - LCBB

 

Stéphanie Courtiol-Legourd

Steph Courtiol


PhD student

UMR 8182, ICMMO
Institut de Chimie Moléculaire et des Matériaux d’Orsay
Université Paris-Sud, Bât 420
91405 Orsay Cedex (France)

Tel: +33 1 69 15 63 11
Fax: +33 1 69 15 72 81

send an email

 

Research interests: Subject 1

Design, synthesis and evaluation of "phosphomimics" inhibitors of aldose-ketose isomerases and their deliverable prodrugs.

Teaching:

PCEM


Licence de chimie L2
Organic chemistry
Analytical Chemistry

Publications:

Synthesis and evaluation of malonate-based inhibitors of phosphosugar-metabolizing enzymes : class II fructose-1,6-bis-phosphate alodolases, type I phosphomannose isomerase, and phosphoglucose isomerase.
S. DESVERGNES, S. COURTIOL-LEGOURD, R. DAHER, M. DABROWSKI, L. SALMON, M. THERISOD
Bioorg. Med. Chem. 2012, 20, 1511-1520.

Polarizable water networks in ligand-metalloprotein recognition. Impact on the relative complexation energies of Zn-dependent phosphomannose isomerase with D-mannose 6-phosphate surrogates.
N. GRESH, B. de COURCY, J.-P. PIQUEMAL, J. FORET, S. COURTIOL-LEGOURD, and L. SALMON
J. Phys. Chem. B 2011, 115, 8304-8316.


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