Institut de Chimie Moléculaire et des Matériaux d'Orsay

Chimie Peptidomimétique Photochimie, Procédés Alternatifs - CP3A






  • " Photochemical Synthesis of Four-membered Ring Amino Acids " Aitken David J. EPA Newsletter 2012, December, 34-37 [PDF]
  • " Study of the Lithiated Phenylacetonitrile Monoanions and Dianions Formed According to the Lithiated Base Used (LHMDS, LDA, or n-BuLi). 2. Alkylation and Deuteriation Mechanism Study by Vibrational and NMR Spectroscopy and Quantum Chemistry Calculations " Strzalko Tekla, Wartski Lya, Corset Jacques, Castella-Ventura Martine, Froment Francoise J. Org. Chem. 2012, 77, 6431-6442 [PDF]
  • " Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors " Juknaitė Lina, Venskutonytė Raminta, Assaf Zeinab, Faure Sophie, Gefflaut Thierry, Aitken David J., Nielsen Birgitte, Gajhede Michael, Kastrup Jette, Bunch Lennart, Frydenvang Lennart, Pickering Darryl J. Struct. Biol. 2012, 180, 39-46 [PDF]
  • " 1-Aminocyclopropane-1-carboxylic acid oxidase: insight into cofactor binding from experimental and theoretical studies " Brisson Lydie, El Bakkali-Taheri Nadia, Giorgi Michel, Fadel Antoine, Kaizer Jozsef, Réglier Marius, Tron Thierry, Ajandouz El Hassan , Simaan A. Jalila J. Biol. Inorg. Chem. 2012, 17, 939-949 [PDF]
  • " Very high stereoselectivity in organocatalyzed desymmetrizing aldol reactions of 3-substituted cyclobutanones " Aitken David J., Bernard Angela M., Capitta Francesca, Frongia Angelo, Guillot Régis, Ollivier Jean, Piras Pier Paolo, Secci Francesco, Spiga Marco Org. Biomol. Chem. 2012, 10, 5045-5048 [PDF]
  • " [2,3]-Sigmatropic Rearrangement of Ynamides: Preparation of α-Amino Allenephosphonates " Gomes Filipe, Fadel Antoine, Rabasso Nicolas J. Org. Chem. 2012, 77, 5439-5444 [PDF]
  • "Hexamethyldisilane" Giros Audrey Synlett 2012, 805-806 [PDF]
  • " Evaluation of an aza-Michael approach for the synthesis of 3,3-dimethyl-2-aminocyclobutane-1-carboxylic acid " Charnay-Pouget Florence, Franck Michael, Baltaze Jean-Pierre, Periera Elisabeth, Aitken David J. ARKIVOC 2012, v, 80-93 [PDF]
  • " Solvent-free stereoselective organocatalyzed aldol reaction of 2-hydroxycyclobutanone " Aitken David J., Capitta Francesca, Frongia Angelo, Ollivier Jean, Piras Pier Paolo, Secci Francesco Synlett 2012, 727-730 [PDF]
  • " Pyrrolidinyl peptide nucleic acid homologues: Effect of ring size on hybridization properties " Mansawat Woraluk, Vilaivan Chotima, Balázs Árpád, Aitken David J., Vilaivan Tirayut Org. Lett. 2012, 14, 1440–1443 [PDF]
  • " Analysis of NAD 2D-NMR Spectra of Saturated Fatty Acids in Polypeptide Aligning Media by Experimental and Modeling Approaches " Serhan Zeïnab, Billault Isabelle, Borgogno A., Ferrarini A., Lesot Philippe Chem. Eur. J. 2012, 18, 117-126 (couverture du journal)



  • " Stereoselective preparation of β,γ-methano-GABA derivatives " Aitken David J., Drouin Ludovic, Goretta Sarah, Guillot Régis, Ollivier Jean, Spiga Marco Org. Biomol. Chem. 2011, 9, 7517-7524 [PDF]
  • " A refined synthesis of enantiomerically pure 2-aminocyclobutanecarboxylic acids " Declerck Valérie, Aitken David J. Amino Acids 2011, 41, 587-595 [PDF]
  • " Preparation of unsymmetrical dialkyl acetylenedicarboxylates and related esters by enzymatic transesterification " Sultan Nisrine, Thomas Coralie, Blanco Luis, Deloisy Sandrine Tetrahedron Lett. 2011, 52, 3443-3446 [PDF]
  • " The First Organocatalysed Direct Aldol Reaction of 2-Hydroxycyclobutanone " Aitken David J., Capitta Francesca, Frongia Angelo, Gori Didier, Guillot Régis, Ollivier Jean, Piras Pier Paolo, Secci Francesco, Spiga Marco Synlett 2011, 712-716 [PDF]
  • " Highly Regio- and Stereoselective Nickel-Catalyzed Addition of Dialkyl Phosphites to Ynamides: an Efficient Synthesis of β-Aminovinylphosphonates " Fadel Antoine, Legrand Frédéric, Evano Gwilherm, Rabasso Nicolas Adv. Synth. Catal. 2011, 353, 263-267 [PDF]
  • " Rapid access to cis-cyclobutane γ-amino acids in enantiomerically pure form " André Virginie, Vidal Anne, Ollivier Jean, Robin Sylvie, Aitken David J. Tetrahedron Lett. 2011, 52, 1253-1255 [PDF]
  • " N-Aminoazetidinecarboxylic Acid: Direct Access to a Small-Ring Hydrazino Acid " Declerck Valérie, Aitken David J. J. Org. Chem. 2011, 76, 708-711 [PDF]
  • " Short and efficient synthesis of 2H-pyrroles from 7-oxanorbornadiene derivatives " Soret Adrien, Müller Christine, Guillot Régis, Blanco Luis, Deloisy Sandrine Tetrahedron 2011, 67, 698-705 [PDF]
  • " Unexpected Synthesis of Optically Active 4-Substituted-5-hydroxy-γ-lactams by Organocatalyzed Reaction of 3-Substituted-Cyclobutanones with Nitrosobenzene " Capitta Francesca, Frongia Angelo, Ollivier Jean, Piras Pier Paolo, Secci Francesco Synlett 2011, 89-93 [PDF]
  • " Synthesis of an enkephalin analogue containing an α,α-disubstituted heterocyclic aminophosphonic acid " Rabasso Nicolas, Fadel Antoine Phosphorus, Sulfur Silicon Relat. Elem. 2011, 186, 1811-1819 [PDF]
  • " New preparation of (Z)-1-phenyl-3-cyano-2-propen-1-ones " Trabulsi Houssam, Rousseau Gérard Synthetic Communications 2011, 41, 2123-2134 [PDF]



  • " Click Chelators. The behaviour of platinum and palladium complexes in the presence of guanosine and DNA " Chevry Aurélien, Teyssot Marie-Laure, Maisonial Aurélie, Lemoine Pascale, Viossat Bernard, Traïkia Mounir, Aitken David J., Alves Georges, Morel Laurent, Nauton Lionel, Gautier Arnaud Eur. J. Inorg. Chem. 2010, 3513-3519 [PDF]
  • " Polymer-Supported α-Aminonitriles: Alkylation Reactions and Carbonyl Compound Cleavage " Virginie Beaufort-Droal, Elisabeth Pereira, Fabrice Vergne, Aitken David J. Synlett 2010, 2913-2917 [PDF]
  • " Oxidation of organic molecules in homogeneous aqueous solution catalyzed by hybrid biocatalysts (based on the Trojan Horse strategy) " Sansiaume Elodie, Ricoux Rémy, Gori Didier, Mahy Jean-Pierre Tetrahedron: Asymmetry 2010, 21, 1593-1600 [PDF]
  • " An expedient asymmetric synthesis of N-protected (S,S)-2-aminomethyl-1-cyclopropanecarboxylic acid " Aitken David J., Bull Steven, Davies Iwan, Drouin Ludovic, Ollivier Jean, Peed Jennifer Synlett 2010, 2729-2732 [PDF]
  • "Chemistry of 4-Hydroxy-2-cyclopentenone Derivatives " Roche Stéphane, Aitken David J. Eur. J. Org. Chem. 2010, 5339–5358 [PDF]
  • " 12-Helix Folding of Cyclobutane β-Amino Acid Oligomers " Fernandes Carlos, Faure Sophie, Pereira Elisabeth, Théry Vincent, Declerck Valérie, Guillot Régis, Aitken David J. Org. Lett. 2010, 12, 3606-3609 [PDF]
  • "endo-6-(Hydroxymethyl)bicyclo[3.1.0]hept-3-en-2-one esters and the photochemical challenge: [2+2] cycloaddition versus skeletal rearrangement " Le Liepvre Matthieu, Ollivier Jean, Aitken David J. Tetrahedron: Asymmetry 2010, 21, 1480-1485 [PDF]
  • " Preparation of imino lactones by electrophilic cyclization of β,γ-unsaturated hydroxamates. Formation of 3-cyano-2-propen-1-ones by a fragmentation reaction " Trabulsi Houssam, Guillot Régis, Rousseau Gérard Eur. J. Org. Chem. 2010, 5884–5896 [PDF]
  • "Titanium-Mediated Cyclopropanation on Diesters: Mechanistic Study on the Dramatic Effects of Selected Parameters " Jida Mouhamad, Gaucher Xavier, Ollivier Jean Synlett 2010, 1627-1630 [PDF]
  • "Synthesis of new β- and γ-aminopyrrolidinephosphonates via 1,3-dipolar cycloaddition of substituted vinylphosphonates" Rabasso Nicolas, Fadel Antoine Tetrahedron Lett. 2010, 51, 60-63 [PDF]



  • "Solid-phase cleavage by a thermal retro-Diels-Alder reaction: preparation of a small β-substituted α,β-ethylenic aldehydes library" Albert Sébastien, Blanco Luis, Deloisy Sandrine Arkivoc 2009, (Xiii), 78-96 [PDF]
  • "Concise total asymmetric synthesis of (S)-2-phenyl-piperidin-3-one " Gaucher Xavier, Jida Mouhamad, Ollivier Jean Synlett 2009, 3320-3322 [PDF]
  • "Synthesis of Functionalized Bicyclo[3.2.0]heptanes: a Study of the [2+2] Photocycloaddition Reactions of 4-Hydroxycyclopent-2-enone Derivatives" Le Liepvre Matthieu, Ollivier Jean, Aitken David J. Eur. J. Org. Chem. 2009, 5953-5962 [PDF]
  • " Highly stereoselective synthesis of new α-amino-β-hydroxy six-membered heterocyclic phosphonic acid, Serine analogues " Louaisil Nicolas, Rabasso Nicolas, Fadel Antoine Tetrahedron 2009, 65, 8587-8595 [PDF]
  • " Enantiotopic discrimination in the palladium-mediated nucleophilic substitutions on achiral substrate: chiral ligand versus chiral nucleophile " Jacquet Olivier, Charnay-Pouget Florence, Fiaud Jean-Claude, Ollivier Jean Synthesis 2009, 3047-3050 [PDF]
  • "Expedient Preparation of All Isomers of 2-Aminocyclobutanecarboxylic Acid in Enantiomerically Pure Form" Fernandes Carlos, Pereira Elisabeth, Faure Sophie, Aitken David J. J. Org. Chem. 2009, 74, 3217-3220 [PDF]
  • "Passerini Reaction−Amine Deprotection−Acyl Migration Peptide Assembly: Efficient Formal Synthesis of Cyclotheonamide C" Faure Sophie, Hjelmgaard Thomas, Roche Stéphane, Aitken David J. Org. Lett. 2009, 11, 1167-1170 [PDF]



  • "Total Synthesis of Cyclotheonamide C by Use of an α-Keto Cyanophosphorane Methodology for Peptide Assembly" Roche Stéphane P., Faure Sophie, El Blidi Lahssen, Aitken David J. Eur. J. Org. Chem 2008, 5067-5078 [PDF]
  • "Convenient Formal Synthesis of (+)-Grandisol through Promoted Lewis Acid Enantioselective Pinacolic Rearrangement" Frongia Angelo, Girard Christian, Ollivier Jean, Piras Pier Paolo, Secci Francesco Synlett 2008, 2823-2825 [PDF]
  • "First synthesis of enantiomerically pure (1S,2S)- and (1R,2R)-1,2-diaminocyclobutanecarboxylic acid–ornithine derivative–, from racemic 2-aminocyclobutanone" Hazelard Damien, Fadel Antoine, Guillot Régis Tetrahedron: Asymmetry 2008, 19/17, 2063-2067 [PDF]
  • "Total Synthesis of Cyclotheonamide C using a Tandem Backbone-Extension-Coupling Methodology" Roche Stéphane P., Faure Sophie, Aitken David J. Angew. Chem. 2008, 6840-6842 [PDF]
  • "Convergent and selective synthesis of pyrrolidinones, piperidinones, dihydropyridinones and pyridinols from a common intermediate. Potential precursors of bioactive products." Jida Mouhamad, Ollivier Jean Eur. J. Org. Chem 2008, 4041-4049 [PDF]
  • "Synthesis of 1-Silabicyclo[4.4.0]dec-5-en-4-ones: A Model of the A and B Rings 1 of 10-Silatestosterone" Díez-González Silvia, Paugam Renée, Blanco Luis Eur. J. Org. Chem 2008, 3298-3307 [PDF]
  • "Synthesis of 2-methylidene-1-silacyclohexanes by intramolecular hydrosilylation" Díez-González, Silvia, Blanco Luis J. Organomet. Chem. 2008, 693/11, 2033-2040 [PDF]
  • " Preparation of halo enol phostones by reaction of acetylenic phosphonate monoesters with (bis-collidine)halo hexafluorophosphate " André Virginie, Robin Sylvie, Rousseau Gérard Tetrahedron Lett. 2008, 49, 5059-5062 [PDF]
  • "Synthesis of New (3-Aminopyrrolidin-3-yl)phosphonic Acid – A Cucurbitine Analogue – and (3-Aminotetrahydrothiophen-3-yl)phosphonic Acid via Phosphite Addition to Heterocyclic Hydrazones" Rabasso Nicolas, Fadel Antoine Synthesis 2008, 2353-2362 [PDF]
  • "Photochemical behaviour of 5-formyl and 5-acetyluracils in the presence of ethene" Periera Elisabeth, Faure Sophie, Aitken David J. Tetrahedron Lett. 2008, 49/12, 1968-1970 [PDF]
  • "Rapid Assembly of the Polyhydroxylated  β-Amino Acid Constituents of Microsclerodermins C, D,and E" Hjelmgaard Thomas, Faure Sophie, Lemoine Pascale, Viossat Bernard, Aitken David J. Org. Lett. 2008, 10/5, 841-844 [PDF]
  • "Click Chelators for Platinum-Based Anticancer Drugs" Mainsonal Aurélie, Serafin Patrycja, Traïkia Mounir, Debiton Eric, Théry Vincent, Aitken David J., Lemoine Pascale, Viossat Bernard, Gautier Arnaud Eur. J. Inorg. Chem. 2008, 298-305 [PDF]
  • "Efficient synthesis of 3-hydroxymethylated cis- and trans-cyclobutane β-amino acids using an intramolecular photocycloaddition strategy" Mondière Aurélie, Peng Runhui, Remuson Roland, Aitken David J. Tetrahedron 2008, 64/6, 1088-1093 [PDF]


  • "Azabicyclo[3.1.0]hexane-1-ols as frameworks for the asymmetric synthesis of biologically active compounds" Jida Mouhamad, Guillot Régis, Ollivier Jean Tetrahedron Lett. 2007, 48/49, 8765-8767 [PDF]
  • "Unexpected Vinyl Transfer in the Titanium-Mediated Cyclopropanation Reaction" Garnier Jean-Marc, Lecornué Frédéric, Charnay-Pouget Florence, Ollivier Jean Synlett 2007, 2827-2828 [PDF]
  • "[2+2] Photocycloadditions with Chiral Uracil Derivatives: Access to All Four Stereoisomers of 2-Aminocyclobutanecarboxylic Acid" Fernandes Carlos, Gauzy Christine, Yang Yi, Roy Olivier, Pereira Elisabeth, Faure Sophie, Aitken David J. Synthesis 2007, 2222-2232 [PDF]
  • "Reaction of unsaturated phosphonate monoesters with bromo- and iodo(bis-collidine) hexafluorophosphates" André Virginie, Lahrache Hind, Robin Sylvie, Rousseau Gérard Tetrahedron 2007, 63/40, 10059-10066 [PDF]
  • "Preparation of Enantiopure 3,5,5-Trialkyl-g-Butyrolactones by Diastereospecific 5-endo Halo Lactonizations" Garnier Jean-Marc, Robin Sylvie, Guillot Régis, Rousseau Gérard Tetrahedron: Asymmetry 2007, 18/12, 1434-1442 [PDF]
  • "Synthesis of (+)-coniceine via reductive photocyclization of dienamides: an entry to indolizidines" Hjelmgaard Thomas, Gardette Daniel, Tanner David, Aitken David J. Tetrahedron: Asymmetry 2007, 18/5, 671-678 [PDF]
  • "An approach to enantioselective 5-endo halo lactonization." Garnier Jean-Marc, Robin Sylvie, Rousseau Gérard Eur. J. Org. Chem. 2007, 3281-3291 [PDF]
  • "A Highly Stereocontrolled Formal Total Synthesis of (±)- and of  (-)-Grandisol by 1,4-Conjugated Addition of Organocopper Reagents to Cyclobutylidene Derivatives" Bernard Angela, Frongia Angelo, Ollivier Jean, Piras Pier Paolo, Secci Francesco, Spiga Marco Tetrahedron 2007, 63/23, 4968-4974 [PDF]
  • "Stereoselective 1,3-Dipolar Cycloaddition of a Maleate Derivative with Azomethine Ylides Derived from α-Amino Esters : Synthesis of 3-Pyrrolines." Soret Adrien, Guillot Régis, Rousseau Gérard, Blanco Luis, Deloisy Sandrine Synlett 2007, 1284-1288 [PDF]
  • "Convenient Formal Synthesis of (±)-Cuparene, (±)-Enokipodins A, B and (±)-Cuparene-1,4-Quinone" Secci Francesco, Frongia Angelo, Ollivier Jean, Piras Pier Paolo Synthesis 2007, 999-1002 [PDF]
  • "Soluble and Polymer-supported 2- and 3-Benzylated Furans for the Preparation of α,β-Ethylenic Carbonyl Compounds." Albert Sébastien, Soret Adrien, Blanco Luis, Deloisy Sandrine Tetrahedron 2007, 63/13, 2880-2900 [PDF]
  • "Asymmetric Synthesis of (R)- and (S)-Amino-3-piperidinyl-phosphonic Acids via Phosphite Addition to Iminium Ions." Louaisil Nicolas, Rabasso Nicolas, Fadel Antoine Synthesis 2007, 289-293 [PDF]
  • "An efficient synthesis of enantiomerically pure (R)-pipecolic acid, (S)-proline and their N-alkylated derivatives." Lahrache Nabil, Fadel Antoine J. Org. Chem. 2007, 72/5, 1780-1784 [PDF]


  • "Stereoselective synthesis of (1R,2R)-1-amino-2-hydroxycyclobutanecarboxylic acid – serine derivative – , from racemic or optically active 2-benzyloxycyclobutanone." Hazelard Damien, Fadel Antoine, Girard Christian Tetrahedron: Asymmetry 2006, 17, 1457-1464 [PDF]
  • "Synthesis of a-amino tetrahydropyranyl-, tetrahydrothiopyranyl-,  4- and 3-piperidinyl- phosphonic acids via phosphite addition to iminium ions." Rabasso Nicolas, Louaisil Nicolas, Fadel Antoine Tetrahedron 2006, 62, 7445-7454 [PDF]
  • "Heterocyclic Compounds with a Silicon Atom and another non-Adjacent Different Heteroatom." Rousseau Gérard, Blanco Luis Tetrahedron 2006, 62, 7951-7993 [PDF]
  • "An Unusual and Stereoselective Michael Addition of a-Amino Ester- Derived N-Lithiated Azomethine Ylides." Soret Adrien, Blanco Luis, Deloisy Sandrine Lett. Org. Chem. 2006, 3, 648-653 [PDF]
  • "Synthesis of 2-methylidene-1-silacyclohexanes from 2,6-dibromohex-1-ene and polyhalosilanes." Blanco Luis, Diez-Conzales Sylvia J. Organomet. Chem. 2006, 691/26, 5531-5539 [PDF]
  • "P-Allyl palladium complexes as efficient and powerful alternative for nucleophilic substitution on bicyclo[3.1.0]hexane sulfonates: regio-, chemo- and stereoselectivity." Ollivier Jean, Lecornué Frédéric, Charnay-Pouget Florence Synlett 2006, 1407-1409 [PDF]
  • "Regio- and Stereoselectivity in the Titanium-Mediated Cyclopropanation of w-alkenoic Diesters: Application in the Diastereoselective Synthesis of Pyrrolidinone." Ollivier Jean, Jida Mouhamad, Garnier Jean-Marc Synlett 2006, 2739-2742 [PDF]