Institut de Chimie Moléculaire et des Matériaux d'Orsay

Chimie Peptidomimétique Photochimie, Procédés Alternatifs - CP3A

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Procédés alternatifs et chimie verte

Soluble polymer-supported flow synthesis

We have shown that a PEG-supported multistep synthesis could be achieved in aqueous media under continuous flow conditions. PEG2000 offers a good compromise between charge capacity and recovery rate by ultrafiltration. The coupling of flow synthesis in water with ultrafiltration reduces the use of organic solvents in both the synthetic and purification steps, and allows safer working conditions.

See also “Chemistry in alternative reaction media”

reference: Soluble polymer-supported flow synthesis: A green process for the preparation of heterocycles, Nicolò Prosa, Raphaël Turgis, Riccardo Piccardi, and Marie-Christine Scherrmann, Eur. J. Org. Chem. 2012, 2188–2200. DOI: 10.1002/ejoc.201101726